Volume 19 Supplement 1
Near-infrared spectroscopy for assessing the tissue oxygen extraction rate during sepsis: relationship with outcome
© Donati et al.; licensee BioMed Central Ltd. 2015
Published: 16 March 2015
Microcirculatory dysfunction impairs tissue oxygenation during sepsis. We applied near-infrared spectroscopy (NIRS) to evaluate the tissue oxygen extraction rate in sepsis and its relationship with outcome.
A prospective observational study; 14 septic patients underwent NIRS monitoring (thenar eminence) with a vascular occlusion test (using a 40% StO2 target) at admission to the ICU. Healthy volunteers (n = 27) were studied as controls. The slope of the desaturation curve was assessed separately for the first (StO2 down1) and the last part (StO2 down2) of the curve and the difference between, Down2 - Down1, was calculated.
Tissue oxygen extraction was reduced in septic patients. Nonsurvivors showed a flattening in the last part of the desaturation curve during a VOT, while the first part of the StO2 downslope did not show any difference between survivors and nonsurvivors. This may reflect a tissue hypometabolic status, which may be better elicited in the final part of the ischemic challenge.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.