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Volume 19 Supplement 1

35th International Symposium on Intensive Care and Emergency Medicine

Eosinopenia as a marker of sepsis and mortality in critically ill patients

Critical Care volume 19, Article number: P47 (2015) Cite this article

Introduction

The idea of using the eosinophil count (EC) as a diagnostic marker for clarifying the nature of systemic inflammatory response syndrome (SIRS) belongs to K Abidi, who showed that EC could be used as a diagnostic criterion of sepsis. There are no published data to define the role of dynamic control of EC in the process of intensive therapy as a prognostic marker and indicator of severity condition in critically ill patients. The aim was to determine the informative value of EC in the development of SIRS as a biomarker of sepsis and indicator of the severity condition and prognosis of outcome in the pathological process.

Methods

A total of 143 patients were enrolled in this study who were admitted to the ICU and had SIRS. All patients were divided into a septic group - patients with community-acquired pneumonia, complicated by sepsis - and two SIRS groups of noninfectious genesis - patients who had an acute cerebrovascular accident (CVA) and an acute myocardial infarction (AMI). The absolute EC was measured at admission and in the dynamics on days 3 to 5 of stay.

Results

The median EC was 75 cells/mm3 in septic patients on admission, which was significantly lower than in patients with CVA (120 cells/mm3) and AMI (130 cells/mm3). Comparison of EC in septic patients between survivors and those who died showed significant differences (Table 1). Receiver operating characteristic (ROC) analysis determined a value less than 80 cells/mm3 as the optimal diagnostic cutoffvalue with a high level of confidence in the comparison of septic and noninfectious groups. Area under the ROC curves was 0.94, sensitivity of 80.8%, specificity of 95.6%, P < 0.0001. There was a significant increase of EC in survivors, while the EC did not change significantly among those who died in the dynamics. ROC analysis determined the cutoff values of EC, which indicated a high risk of an adverse outcome in septic patients (Table 2).

Table 1 Dynamics of eosinophil count depending on outcome in groups.
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Table 2 Informational value of eosinophil count in assessment of disease outcome.
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Conclusion

EC may be an additional diagnostic marker which characterizes the nature of SIRS. Eosinopenia associated with prognosis of outcome in critical conditions.

Author information

Affiliations

  1. City Clinical Hospital # 40, Yekaterinburg, Russia

    A Savitskiy, V Rudnov & V Bagin

Authors
  1. A Savitskiy
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  2. V Rudnov
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  3. V Bagin
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Correspondence to A Savitskiy.

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Savitskiy, A., Rudnov, V. & Bagin, V. Eosinopenia as a marker of sepsis and mortality in critically ill patients. Crit Care 19, P47 (2015). https://doi.org/10.1186/cc14127

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Keywords

  • Receiver Operating Characteristic
  • Acute Myocardial Infarction
  • Receiver Operating Characteristic Curve
  • Acute Myocardial Infarction
  • Acute Cerebrovascular Accident

Critical Care

ISSN: 1364-8535