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Tyrosine metabolism disorder and the potential capability of anaerobic microbiota to decrease the value of aromatic metabolites in critically ill patients
© Beloborodova et al.; licensee BioMed Central Ltd. 2014
Published: 3 December 2014
In surviving patients (n = 24) the total level of p-HPLA and p-HPAA (4.47; 3.24 to 8.35 µM) was less (P < 0,001) than in patients who died (n = 41) (13.67; 5.78 to 52.26 µM). The severity of organ dysfunction on a SOFA scale correlates (rs = 0.7, P < 0.001) with the total level of the p-HPLA and p-HPAA. Also the total level of aromatic compounds correlates with lactate (rs = 0.6; P < 0.001), BE (rs = -0.5, P < 0.001) and perfusion blood pressure (rs = -0.5, P < 0.001). ROC analysis revealed that p-HPLA has the largest area under the curve (0.78; CI 0.67 to 0.90, P < 0.001). In experimental studies, anaerobic bacteria significantly reduced the level of p-HPAA and p-HPLA (Figure 2).
High level of p-HPLA and p-HPAA correlate with severity and mortality of patients. Hypoxia can be one of the leading mechanisms of tyrosine metabolism disorders in critically ill patients. Bacteroides spp. are able to consume p-HPLA and p-HPAA and consequently may be involved in the elimination of these intermediates from the human body mutually with endogenous mechanisms of detoxification.
This work was supported by the Russian Foundation for Basic Research (project number 1304-01758/13).
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