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Blood sugar variation during the first 48 hours of hospitalization for patients with sepsis was associated with in-hospital mortality
© Chen and Wu; licensee BioMed Central Ltd. 2014
Published: 3 December 2014
Blood sugar control for patients with sepsis remains controversial. We aimed to test the hypothesis that the variation of blood sugar level is associated with patient outcome in this study.
A retrospective cohort study on nontraumatic adult patients who visited the ED of a tertiary hospital in 2010 and had a clinical diagnosis of severe sepsis was conducted. Patients with two sets of blood culture ordered by emergency physicians and at least two blood sugar tests results available during the first 48 hours of hospitalization were included. The coefficients of variation (CoV, the ratio of the standard deviation to the mean) of the blood sugar level were analyzed with multivariate logistic regression models to test the association between in-hospital mortality.
Sugar CoV <10%
Sugar CoV >30%
Initial sugar level <100
Initial sugar level ≥ 100 and <500
Initial sugar level higher ≥ 500
Previous diagnosis of diabetes
Severity of sepsis
In this retrospectively cohort study, we found that increased blood sugar variation was associated with worse patient outcome. However, further study is merited to test the possible causal relationship between variation of blood sugar level and patient outcome.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.