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Physiological changes after fluid bolus therapy in sepsis: a systematic review of the contemporary literature
© Glassford et al.; licensee BioMed Central Ltd. 2014
Published: 3 December 2014
Fluid bolus therapy (FBT) is a ubiquitous intervention in intensive care. However, the physiological effects in the critically ill are poorly understood. Therefore, we systematically reviewed the contemporary literature to determine the current practice and effect of FBT in the management of severe sepsis and septic shock.
We interrogated the MEDLINE, CENTRAL and EMBASE electronic reference databases using a combination of terms to define a set of records of studies of fluid administration in patients with severe sepsis or septic shock. To achieve contemporary relevance, results were limited to English-language studies in adults between 2010 and 2013.
There is a need for obtaining randomised controlled evidence for the physiological effects of FBT in patients with severe sepsis and septic shock beyond the period immediately following its administration.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.