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Multiple organ dysfuntion in ARDS


The multiple organ dysfunction syndrome (MODS) is a major cause of mortality in ARDS. However, there are few studies evaluating this relationship using new score systems for MODS.


All patients in the ICU who met American-European Consensus criteria for ARDS [1] between November 1998 and December 2000 were included in the analysis. Criteria for MODS were those proposed by Marshall et al [2]. Age, gender, APACHEII score and outcome were also evaluated. The patients were divided into survivors (SV) and nonsurvivors (NSV). The differences between groups were analyzed with t-test, ?2 and Mann-Whitney as indicated.


There were 975 admissions to the ICU, of whom 64 (6.6%) presented ARDS criteria. The mean age was 35 ± 13 years and 54 ± 16 years (P < 0.001), and the APACHEII was 16.4 ± 3.3 and 20 ± 5.2 (P = 0.02) in SV and NSV, respectively. General mortality was 79% (n = 51), 39% (n = 20) in females and 61% (n = 31) in males (P = 0.066). The results of the MODS in SV and NSV are shown in the Table.



The severity of MODS measured by a specific score is associated with increased mortality in ARDS. Advanced age, male gender and individual dysfunction of renal and hepatic systems were associated with a poor prognosis.


  1. Am J Respir Crit Care Med 1994, 273: 306.

  2. Crit Care Med 1995, 23: 1638-1652. 10.1097/00003246-199510000-00007

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Dias, F., Almeida, N., Wawrzeniak, I. et al. Multiple organ dysfuntion in ARDS. Crit Care 5 (Suppl 3), P61 (2001).

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