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Erratum to: The effect of glutamine therapy on outcomes in critically ill patients: a meta-analysis of randomized controlled trials

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Critical Care201418:436

  • Published:

The original article was published in Critical Care 2014 18:R8

After publication of our article in a recent issue of Critical Care[1], inconsistencies were identified in Figure 6. Four trials - by Fuentes-Orozco and colleagues [2, 3], Hall and colleagues [4], and Goeters and colleagues [5] - were allocated to the wrong subgroup in our meta-analysis. They should have been included in the first subgroup (glutamine <0.3 g/kg per day); this does not change the significance of the results (P = 0.01). The correct Figure 6 is given here in full as Figure 1.
Figure 1
Figure 1

A subgroup meta-analysis of the effects of different dosages of glutamine on mortality in critically ill patients (fixed effects models). CI, confidence interval; M-H, Mantel-Haenszel.



Authors’ Affiliations

Department of Critical Care Medicine, Zhong-Da Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, P.R. China
Department of Critical Care Medicine, Su-Bei Hospital of Jiangsu Provience & Clinical Medical School, Yangzhou University, Yangzhou, Jiangsu, P.R. China


  1. Chen QH, Yang Y, He HL, Xie JF, Cai SX, Liu AR, Wang HL, Qiu HB: The effect of glutamine therapy on outcomes in critically ill patients: a meta-analysis of randomized controlled trials. Crit Care. 2014, 18: R8-10.1186/cc13185.PubMedPubMed CentralView ArticleGoogle Scholar
  2. Fuentes-Orozco C, Anaya-Prado R, González-Ojeda A, Arenas-Márquez H, Cabrera-Pivaral C, Cervantes-Guevara G, Barrera-Zepeda LM: L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis. Clin Nutr. 2004, 23: 13-21. 10.1016/S0261-5614(03)00055-4.PubMedView ArticleGoogle Scholar
  3. Fuentes-Orozco C, Cervantes-Guevara G, Muciño-Hernández I, López-Ortega A, Ambriz-González G, Gutiérrez-de-la-Rosa JL, Gómez-Herrera E, Hermosillo-Sandoval JM, González-Ojeda A: L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis. JPEN J Parenter Enteral Nutr. 2008, 32: 403-411. 10.1177/0148607108319797.PubMedView ArticleGoogle Scholar
  4. Hall JC, Dobb G, Hall J, de Sousa R, Brennan L, McCauley R: A prospective randomized trial of enteral glutamine in critical illness. Intensive Care Med. 2003, 29: 1710-1716. 10.1007/s00134-003-1937-2.PubMedView ArticleGoogle Scholar
  5. Goeters C, Wenn A, Mertes N, Wempe C, Van Aken H, Stehle P, Bone HG: Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients. Crit Care Med. 2002, 30: 2032-2037. 10.1097/00003246-200209000-00013.PubMedView ArticleGoogle Scholar


© Chen et al.; licensee BioMed Central Ltd. 2014

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