- Poster presentation
- Published:
Vitamin D level could affect the recovery rate in traumatic brain injury: a retrospective study
Critical Care volume 18, Article number: P471 (2014)
Introduction
Recent studies have shown that 1,25-dihydroxyvitamin D3 (vitamin D) deficiency may affect negatively the clinical course of traumatic brain injury (TBI) [1]. This problem becomes important with respect to the older patient considering a 50% prevalence of vitamin D deficiency [2]. Data from the Third National Health and Nutrition Examination Survey [3] document more than 60% of Caucasians affected by D deficiency [4] so that all patients with TBI of any age are theoretically at risk of unfavorable outcome [2]. The objective of this preliminary study was to determine whether low levels of vitamin D at admission to the ICU (<24 hours) could negatively affect neurological recovery of patients with TBI.
Methods
We retrospectively analyzed the data of 46 patients affected by TBI (65% severe, 9.5% moderate, 28.5% moderate) both isolated or associated with other extracranial lesions. The sampling of vitamin D was carried out within 24 hours from ICU admission. We had registered GCS at the moment of presentation (GCS in) and at discharge (GCS out) and their difference (GCS diff) compared with levels of vitamin D. Patients that died in the ICU were assigned a GCS out = 0. See Table 1.
Results
Our data, according to other studies [5], confirm the presence of a deficiency of vitamin D (Table 1); however, they do not demonstrate a statistical significance correlation at the univariate regression (R = 0.04; P = 0.786) between vitamin D level and outcome from the ICU. There was no correlation stratifying patients for age, for TBI class, for Injury Severity Score and for BMI.
Conclusion
Vitamin D deficiency is really prevalent in our TBI cases but does not seem to affect neurological recovery at ICU discharge; however, these preliminary results should be exposed to several criticisms and need to be confirmed with prospective studies.
References
Chatterjee M, et al.: Vitamin D and genomic stability. Mutat Res 2001, 475: 69-87. 10.1016/S0027-5107(01)00080-X
Milos C, et al.: Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease. Neuroendocrinology 2009, 30: 158-172. 10.1016/j.yfrne.2009.04.002
Plan and Operation of the Third National Health and Nutrition Examination Survey. 1988-94. DHHS publication No. (PHS)94-1308 - Vital and Health Statistics, series 1, no. 32. Hyattsville, MD: US Department of Health anc Human Services, Public Health Service, CDC; 1994
Khazai N, et al.: Calcium and vitamin D: skeletal and extraskeletal health. Curr Rheumatol Rep 2008, 10: 110-117. 10.1007/s11926-008-0020-y
Cecchi A, et al.: Vitamin D deficiency in septic patients at ICU admission is not a mortality predictor. Minerva Anest 2011, 77: 1184-1189.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Socci, F., Di Valvasone, S., Cecchi, A. et al. Vitamin D level could affect the recovery rate in traumatic brain injury: a retrospective study. Crit Care 18 (Suppl 1), P471 (2014). https://doi.org/10.1186/cc13661
Published:
DOI: https://doi.org/10.1186/cc13661