Human acute kidney injury is associated with a proinflammatory phenotype
© Gauge et al.; licensee BioMed Central Ltd. 2014
Published: 17 March 2014
Animal research suggests that acute kidney injury (AKI) is an inflammatory condition . Our aim was to describe the immune phenotype in human AKI.
We enrolled patients with: AKI grade II/III (defined by KDIGO criteria) and systemic inflammatory response syndrome (SIRS) without sepsis; SIRS without AKI; and AKI II/III without SIRS. A healthy control population was used for baseline comparison. Serial blood samples were taken on days 0, 2 and 7. Cells were separated using Percoll gradients and phenotyped using flow cytometry.
AKI + SIRS
AKI no SIRS
% CD8+ cytotoxic T cells
% Fr. II T-regulatory cells
% Fr. III cytokine T cell
% CD69+ neutrophils
Human AKI is associated with a proinflammatory phenotype.
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