Volume 18 Supplement 1
Human acute kidney injury is associated with a proinflammatory phenotype
© Gauge et al.; licensee BioMed Central Ltd. 2014
Published: 17 March 2014
Animal research suggests that acute kidney injury (AKI) is an inflammatory condition . Our aim was to describe the immune phenotype in human AKI.
We enrolled patients with: AKI grade II/III (defined by KDIGO criteria) and systemic inflammatory response syndrome (SIRS) without sepsis; SIRS without AKI; and AKI II/III without SIRS. A healthy control population was used for baseline comparison. Serial blood samples were taken on days 0, 2 and 7. Cells were separated using Percoll gradients and phenotyped using flow cytometry.
AKI + SIRS
AKI no SIRS
% CD8+ cytotoxic T cells
% Fr. II T-regulatory cells
% Fr. III cytokine T cell
% CD69+ neutrophils
Human AKI is associated with a proinflammatory phenotype.
- Akcay A, et al.: Mediators of inflammation in acute kidney injury. Mediators Inflamm 2009 2009, 137072.Google Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.