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Acute kidney injury of all severity is associated with extended hospitalization after critical illness

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Introduction

Acute kidney injury (AKI) complicates over 50% of ICU admissions and is associated with significantly increased mortality, length of stay, and costs across a broad spectrum of conditions [1].

Methods

We performed a single-centre, retrospective analysis of AKI diagnosis in patients with ICU admissions of 5 days or more who survived to hospital discharge between 2009 and 2011. We examined the relationship between hospital length of stay, AKI diagnosis, demographics and clinical characteristics in a multivariable Cox-hazard analysis.

Results

We identified 700 cases, with a 66% incidence of AKI. The AKI was associated with older age, greater initial illness severity and longer ICU and hospital length of stay in univariate analysis (Table 1). In Cox-hazard analysis, only AKI category and ICU length of stay were significantly associated with lower probability of discharge over time (Figure 1). AKI-1 was associated with a hazard ratio for hospital discharge of 0.66 (0.55 to 0.79), AKI-2 with 0.55 (0.42 to 0.71) and AKI-3 with 0.54 (0.44 to 0.66).

Table 1 Patient characteristics by AKI
Figure 1
figure1

Cox-hazard prediction of AKI class on hospitalization (ICU LOS fixed at median).

Conclusion

AKI was a significant predictor of remaining in hospital at all levels of AKI severity even after allowing for longer ICU stay. Even mild AKI is associated with extended recovery from critical illness and healthcare costs even after ICU discharge.

References

  1. 1.

    Chertow , et al.: J Am Soc Nephrol. 2005, 11: 3365.

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Author information

Correspondence to JR Prowle.

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Prowle, J., Kolic, I., Purdell-Lewis, J. et al. Acute kidney injury of all severity is associated with extended hospitalization after critical illness. Crit Care 18, P368 (2014). https://doi.org/10.1186/cc13558

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Keywords

  • Emergency Medicine
  • Retrospective Analysis
  • Hospital Discharge
  • Lower Probability
  • Healthcare Cost