Activated protein C consumption and coagulation parameters in severe sepsis and septic shock
© De La Torre-Prados et al.; licensee BioMed Central Ltd. 2014
Published: 17 March 2014
Activated protein C (APC) deficiency is prevalent in severe sepsis and septic shock patients. The aim of the study was to relate the anticoagulation activity evaluated by APC with other coagulation parameters adjusted to 28-day mortality.
A cohort study of 150 critically ill adults. Age, sex, sources of infection and coagulation markers within 24 hours from severe sepsis or septic shock onset, defined according to Surviving Sepsis Campaign (SSC) criteria, were studied. We analyzed APC activity using a hemostasis laboratory analyzer (BCS® XP; Siemens). A descriptive and comparative statistical analysis was performed using SPSS version 15.0 (SPSS Inc., Chicago, IL, USA).
Low levels of PC are associated with poor outcome and severity in severe sepsis, and it is well correlated with antithrombin III and INR.
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