Preoperative therapy with angiotensin-converting enzyme inhibitors in cardiac surgery patients: is there any impact on postoperative renal function?
© Ampatzidou et al.; licensee BioMed Central Ltd. 2014
Published: 17 March 2014
A total of 624 consecutive patients, who underwent cardiac surgery from July 2012 to October 2013, were evaluated. Data were prospectively collected in our clinic's electronic database and were retrospectively analyzed as to preoperative ACEI therapy. The chi- square test was used for correlations. Endpoints of the study were the development of postoperative acute kidney injury (AKI) and the difference between hospital admission and discharge glomerular filtration rate (GFR). The AKI definition was based on modified RIFLE classification. GFR values were estimated by the MDRD formula.
AKI and GFR difference
ACEI users (n= 354)
ACEI nonusers (n= 270)
GFR difference (mean)
The impact of preoperative ACEI treatment on postoperative renal function after cardiac surgery is still debated. We found no association, neither protective nor harmful, between preoperative ACEI therapy and renal function impairment.
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