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Table 2 Main ventilatory variables and inspiratory effort following interventions, at increased settings, with group means differences between FM and SB versus HS and HN

From: Comparative evaluation of three interfaces for non-invasive ventilation: a randomized cross-over design physiologic study on healthy volunteers

 

Increased settings

Group mean difference (95% CI)

 

HS

HN

FM-HS

FM-HN

SBI-HS

SBI-HN

V T ml

882 ± 276

853 ± 278

-286 ± 338*

-257 ± 320*

-95 ± 219

-67 ± 222.

RRn breath/minute

13 ± 4

14 ± 5

1.9 ± 4.5

0.42 ± 3.4

0.42 ± 3.4

-1.08 ± 3.3

V E L/minute

10.6 ± 3.0

11.6 ± 4.7

-2.7 ± 1.9*

-3.6 ± 3.1*

-1.0 ± 2.5

-2.0 ± 3.1

PTPdi/breath

13.0 ± 10.5

10.7 ± 9.9

4.0 ± 5.6*

6.3 ± 7.4*

7.0 ± 9.4*

9.4 ± 10.1*

PTPdi/minute

142 ± 80

128 ± 96

6.8 ± 93.2

75.6 ± 82.7*

44.2 ± 128.7*

113.1 ± 119.2*

PTPdi/L

15.2 ± 10.0

12.6 ± 9.9

9.3 ± 14.5

17.6 ± 13.7*

6.7 ± 15.6

15.0 ± 14.7*

WOB J/breath

0.412 ± 0.313

0.390 ± 0.314

-0.11 ± 0.33

-0.05 ± 0.35

0.01 ± 0.34

0.07 ± 0.33

WOB J/minute

5.04 ± 4.10

5.75 ± 5.79

-2.1 ± 5.9

-1.1 ± 4.6

-1.1 ± 5.6

-0.04 ± 4.0

WOB J/L

0.448 ± 0.233

0.446 ± 0.267

0.02 ± 0.24

0.12 ± 0.25

0.06 ± 0.29

0.17 ± 0.30

Delay,TR-insp (s)

0.345 ± 0.073

0.230 ± 0.061

-0.16 ± 0.09

-0.05 ± 0.08

NA

NA

Delay,TR-exp (s°

0.367 ± 0.074

0.290 ± 0.099

-0.09 ± 0.08

-0.02 ± 0.11

NA

NA

TI,Synchrony (%)

80 ± 5

85 ± 2

9.8 ± 5.9*

4.2 ± 4.1*

NA

NA

  1. Data are presented as mean ± SD and group mean differences ± SD. Data following intervention; n = 12 healthy volunteers included. Increased settings for HS and HN were PEEP 8 cmH2O; PS 8 cmH2O, Ramp 0; Exp trigger: 25%; FiO2: 21%. Data were analyzed with a generalized linear mixed-effects model for repeated measures, *P <0.0125. VT, tidal volume; VE, minute ventilation; RRn, neural respiratory rate; PTPdi, pressure-time product of the transdiaphragmatic pressure; WOB, work of breathing; FM, face mask; HS, helmet standard; HN, helmet next; SBI, initial spontaneous breathing; SBE, end spontaneous breathing; PEEP, positive end-expiratory pressure; PS, pressure support; Exp trigger, expiratory trigger; delay, TR-insp, inspiratory trigger delay; Delay,TR-exp, expiratory trigger delay; TI,Synchrony, synchrony time as% of patient inspiratory time; NA, not applicable.