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Critical Care

Open Access

Leukopenia predicts outcome in haemato-oncological patients requiring intensive care

  • MP Margarson1,
  • AC Gordon1,
  • R A'Hern1 and
  • D Skewes1
Critical Care20015(Suppl 1):P239

Received: 15 January 2001

Published: 2 March 2001


Stem Cell TransplantLeukopeniaAcute LeukaemiaWhite Cell CountNeutropenic Patient


Patients with haematological malignancy who develop respiratory failure have a very poor prognosis [1,2]. The presence of leukopenia at the time of admission has long been suspected to be associated with worse outcome but no published study has convincingly demonstrated this.


Prospectively entered admission and 12 month follow up data from 1222 admissions to an oncological ICU over a 7 year period ending June 1998 were reviewed. We identified 231 haematological (Leukaemia, Lymphoma or Myeloma) admissions. Patients who had received stem cell transplants (SCT) were identified from a separate database and sub-set analyses were performed.

A cross-query of the central haematology laboratory database was set up to determine the total white cell count of each patient prior to and on admission. Leukopenia was defined as an absolute white cell count of < 1.5 × 106/ml. Statistical analyses were by Fisher's exact test.


152 (66%) of the 231 patients died on the unit, a further 26 died within 30 days of leaving the ICU, a total hospital mortality of 77%.

50/107 (48%) of the neutropenic patients were SCT recipients. Excluding 20 patients with acute leukaemia (white cell counts 49.5-850 × 106/ml), 37/100 (37%) of non-neutropenic patients were SCT recipients (P = 0.16).


Haemato-oncological patients have a significantly greater mortality if they are leukopenic at the time of ICU admission: this is not solely attributable to the increased proportion of stem cell transplant recipients in this group. There is an extremely poor prognosis and a strong trend toward increased mortality in patients with pre-admission leukopaenia of more than 7 days duration.
Table 1




30 day

12 month


ICU deaths



< 1.5

83/107 (78%)

91/107 (85%)

98/107 (92%)

> 1.5

69/126 (55%)

86/126 (68%)

107/126 (85%)

P value

< 0.003

< 0.003


Duration of pre-





ICU deaths

30 day mortality

< 7 days

38/54 (70%)

43/54 (80%)

= 7 days

45/53 (85%)

48/53 (91%)

P value



Authors’ Affiliations

Intensive Care Uni, Royal Marsden Hospital, London, UK


  1. Brunet F, et al.: Is intensive care justified for patients with haematological malignancies? Intensive Care Med 1990, 16: 291-297. 10.1007/BF01706352View ArticleGoogle Scholar
  2. Rubenfeld G, Crawford SW: Withdrawing life support from mechanically ventilated recipients of bone-marrow transplants. Ann Int Med 1996, 125: 625-633.View ArticleGoogle Scholar


© The Author(s) 2001