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Figure 1 | Critical Care

Figure 1

From: Gene expression patterns in multiple organs in experimentally induced Staphylococcus aureus sepsis in pigs

Figure 1

Pigs (scores) and genes (loadings) in PC1-PC2 (A, C) and PC1-PC3 space (B, D). (A) Increased PC1 scores are seen in infected pigs from 12 hours until the end of the study (48 hours), with a peak around 24 hours. PC2 scores are increased after 6 hours of infection, with a peak at 12 hours. Thereafter, scores decline towards basal levels, or below. (B) PC3 scores are increased mainly in infected pigs at 6 hours p.i. (C) Genes with largest influence on the PC1 axis are mainly hepatic positive and negative acute phase genes (for example, SAA, ITIH4, TTR, TRF). Genes with largest influence on the PC2 axis are not specifically related to a single tissue. (D) The main influencers of the PC3 axis are inflammatory genes measured in lung tissue. Gene symbols are used according to the National Center for Biotechnology Information (NCBI).

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Critical Care

ISSN: 1364-8535