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Volume 17 Supplement 4

Sepsis 2013

SIRS criteria as predictors of mortality in patients admitted with sepsis


The ACCP/SCCM consensus conference definitions for sepsis are used worldwide [1]. However, consensus definitions do not adequately reflect the intricacies of sepsis and can overestimate the diagnosis due to their high sensitivity. Moreover, the consensus criteria do not allow the staging or the prediction of sepsis outcome [2]. This study aims to evaluate the individual components of SIRS criteria as predictors of mortality in patients admitted to an ICU with sepsis.

Materials and methods

A case-control study conducted in the ICU of Hospital Santa Luzia, Brasilia, DF, Brazil, during 4 months. Patients were divided into two groups: survivors group (SG) and nonsurvivors group (NSG). The accuracy of individual components of SIRS criteria as predictors of mortality was measured with the area under the receiver operating characteristic (ROC) curve.


A total of 76 patients were enrolled, 10.5% (n = 8) with septic shock. Age was 70 ± 18 years, SAPS3: 52.9 ± 13.9, APACHE II: 15.5 ± 8.8. The ICU length of stay was 9 ± 10 days. ICU mortality was 21% (n = 16). The most prevalent sites of infections were respiratory (57.9%, n = 44), followed by urinary (25%, n = 19) and cutaneous (6.6%, n = 5). The incidence of tachycardia was the only parameter higher in the NSG (37.5% vs. 9.1%, P = 0.00). There was no difference regarding the incidence of fever or hypothermia (15.4% vs. 24.0%, P = 0.38), tachypnea (25.0% vs. 17.5%, P = 0.42) or leukocytosis or leucopenia (20.9% vs. 21.2%, P = 0.97) between the groups. The relative risk of death in patients with tachycardia was 4.13 (95% CI: 1.46 to 11.63). Tachycardia also had the larger area under the ROC curve: 0.708 (95% CI: 0.566 to 0.850), versus 0.442 (95% CI: 0.287 to 0.597) for fever/hypothermia, 0.556 (95% CI: 0.397 to 0.715) for tachypnea, and 0.498 (95% CI: 0.338 to 0.658) for leukocytosis/leucopenia.


For this sample, tachycardia was the only SIRS component associated with ICU mortality in patients admitted with sepsis.


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Santana, A.R., de Souza, J.L., Amorim, F.F. et al. SIRS criteria as predictors of mortality in patients admitted with sepsis. Crit Care 17 (Suppl 4), P54 (2013).

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  • Relative Risk
  • Receiver Operating Characteristic
  • Septic Shock
  • Emergency Medicine
  • Receiver Operating Characteristic Curve