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Volume 17 Supplement 4

Sepsis 2013

Open Access

Impact of sepsis on older and nonolder patients: clinical conditions and outcomes

  • Jaqueline Lima de Souza1,
  • Fábio Ferreira Amorim1,
  • Adriell Ramalho Santana1,
  • Felipe Bozi Soares1,
  • Bárbara Magalhães Menezes1,
  • Mariana Pinheiro Barbosa de Araújo1,
  • Fernanda Vilas Bôas Araújo1,
  • Louise Cristhine de Carvalho Santos1,
  • Pedro Henrique Gomes Rocha1,
  • Alessandra Vasconcelos da Silva Paiva1,
  • Gabriel Kanhouche2,
  • Pedro Nery Ferreira Júnior1,
  • Alethea Patrícia Pontes Amorim2,
  • José Aires de Araújo Neto3,
  • Edmilson Bastos de Moura3 and
  • Marcelo de Oliveira Maia3
Critical Care201317(Suppl 4):P53

Published: 5 November 2013


Relative RiskMechanical VentilationSeptic ShockClinical ConditionEmergency Medicine


The increase of the older population, with higher incidence of co-morbidities and age-related decline in organic functions, suggests a need for better understanding the peculiarities of the process leading to adequate critical care in this group of patients [1, 2]. This study aims to evaluate morbimortality of sepsis on older and nonolder patients and its impact on their outcomes.

Materials and methods

Retrospective cohort study conducted in the ICU of Hospital Santa Luzia, Brasilia, DF, Brazil, during 6 months. Patients diagnosed with sepsis were divided into two groups: older, defined as age ≥65 years, and nonolder, with age <65, for the analysis of the outcomes.


A total of 130 patients with sepsis were enrolled, 11.5% (n = 15) with septic shock. Mean age was 64 ± 22 years, ICU length of stay 9.6 ± 13.2 days, SAPS3 50 ± 13. ICU mortality in 4 days was 6.9% (n = 13), in 28 days was 9.2% (n = 12) and hospital morality was 17.7% (n = 23). Seventy patients were older (60.8%). The older patients had higher SAPS3 (56 ± 12 vs. 40 ± 9, P = 0.00), Charlson Comorbidity Index (CCI) (2.4 ± 1.9 vs. 1.0 ± 1.7, P = 0.00), and incidence of Glasgow Coma Scale <15 (19% vs. 5.9%, P = 0.03). There was no difference between the groups regarding the incidence of septic shock (12.7% vs. 9.8%, P = 0.62), need for dialysis (8.9% vs. 7.8%, P = 0.84), vasopressor agents (6.3% vs. 7.8%, P = 0.74) or invasive mechanical ventilation (25.3% vs. 15.7%, P = 0.19). There was also no difference regarding ICU length of stay (15 ± 2 vs. 10 ± 1 days, P = 0.22), mortality in 4 days (8.9% vs. 3.9%, P = 0.28) and in 28 days (12.7% vs. 3.9%, P = 0.09). However, hospital mortality was higher amongst the group of older patients (26.5% vs. 3.9%, P = 0.00). The relative risk of hospital death in older patients was 6.78 (95% CI: 1.66 to 27.68).


Older septic patients had higher SAPS 3, CCI, and incidence of GCS <15. Although there was no difference regarding mortality in 4 and 28 days or ICU length of stay, hospital mortality was higher for this group of patients.

Authors’ Affiliations

Escola Superior de Ciências da Saúde, Brasília, Brazil
Liga Acadêmica de Medicina Intensiva de Brasília, Brazil
Hospital Santa Luzia, Brasília, Brazil


  1. Minne L, Ludikhuize J, de Jonge E, de Rooij S, Abu-Hanna A: Prognostic models for predicting mortality in elderly ICU patients: a systematic review. Intensive Care Med 2011, 37: 1258-1268. 10.1007/s00134-011-2265-6View ArticlePubMedGoogle Scholar
  2. Lerolle N, Trinquart L, Bornstain C, Tadié JM, Imbert A, Diehl JL, Fagon JY, Guérot E: Increased intensity of treatment and decreased mortality in elderly patients in an intensive care unit over a decade. Intensive Care Med 2011, 37: 1258-1268. 10.1007/s00134-011-2265-6View ArticleGoogle Scholar


© de Souza et al.; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.