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Volume 17 Supplement 4

Sepsis 2013

  • Poster presentation
  • Open Access

Platelet/leukocyte ratio as a predictor of mortality in patients with sepsis

  • Bárbara Magalhães Menezes1,
  • Fábio Ferreira Amorim1,
  • Adriell Ramalho Santana1,
  • Felipe Bozi Soares1,
  • Fernanda Vilas Bôas Araújo1,
  • Jacqueline Rodrigues de Carvalho1,
  • Mariana Pinheiro Barbosa de Araújo1,
  • Louise Cristhine de Carvalho Santos1,
  • Pedro Henrique Gomes Rocha1,
  • Jaqueline Lima de Souza1,
  • Mateus Gonçalves Gomes1,
  • Pedro Nery Ferreira Júnior1,
  • Alethea Patrícia Pontes Amorim2,
  • Rodrigo Santos Biondi3 and
  • Rubens Antônio Bento Ribeiro3
Critical Care201317(Suppl 4):P52

Published: 5 November 2013


Cohort StudyPrimary OutcomeHigh MortalityPlatelet CountSeptic Shock


The platelet count is an established index in the evaluation of severity in patients with sepsis, and therefore is a component of the SOFA score [1]. Furthermore, the alterations in leukocyte count are also used in the definition of SIRS. The present study aims to evaluate the accuracy of the platelet/leukocyte ratio (P/L) as a predictor of mortality in septic patients.

Materials and methods

Retrospective cohort study conducted on patients admitted to the ICU of Hospital Anchieta, Brasília, DF, Brazil, during 3 years. The patients with sepsis were divided according to P/L as follows: P/L ≥8 group (HPL) or P/L <8 (LPL). The primary outcome was mortality at 4 and 28 days. Accuracy of P/L to predict ICU mortality was measured with the area under the receiver operating characteristic curve.


In the present study, 195 patients were enrolled, 41% (n = 80) with septic shock. Their mean age was 62.8 ± 21.6 years, SAPS 3 was 62.1 ± 15.0, APACHE II was 20.6 ± 8.6, and length of stay in the ICU was 9 ± 11 days. Mortality at 4 days was 10.8% (n = 21) and at 28 days was 12.3% (n = 24). The groups P/L <8 and P/L ≥8 did not present differences regarding age (59 ± 20 vs. 65 ± 22, P = 0.07) and APACHE II (22 ± 9 vs. 20 ± 9, P = 0.19). The LPL group had higher SAPS3 (68 ± 18 vs. 59 ± 13, P = 0.00). The LPL was significantly associated with mortality in 4 days (18% vs. 7%, P = 0.02) and 28 days (19% vs. 9%, P = 0.03). The area under the ROC curve of P/L for mortality at day 4 was 0.628 (95% CI 0.498 to 0.757) and at day 28 was 0.613 (95% CI 0.489 to 0.736).


P/L <8 at admission was associated with higher mortality in 4 and 28 days in patients with sepsis.

Authors’ Affiliations

Escola Superior de Ciências da Saúde, Brazil
Liga Acadêmica de Medicina Intensiva de Brasília, Brazil
Hospital Anchieta, Brasília, Brazil


  1. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22: 707-710. 10.1007/BF01709751View ArticlePubMedGoogle Scholar


© Menezes et al.; licensee BioMed Central Ltd. 2013

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