- Poster presentation
- Open Access
Prognostic factors in the first hour post admission for intra-hospital mortality in patients with septic shock in an ICU
Critical Care volume 17, Article number: P49 (2013)
Severe sepsis and septic shock are common and are associated with substantial mortality and substantial consumption of healthcare resources . Although the incidence of septic shock has steadily increased during the past several decades, the associated mortality rates have remained constant or have decreased only slightly . Our study aimed to identify the prognostic factors during the first hour after admission for intra-hospital mortality in patients with septic shock in a general ICU.
Materials and methods
Case-control study conducted on patients admitted to the ICU of Hospital Anchieta, Brasília, DF, Brazil, during 17 months. Patients were divided into two groups during the hospital stay: survivors group (SG) and nonsurvivors group (NSG). Patients proceeding from or transferred to another ICUs were excluded.
During the period of the study, 1,918 patients were admitted, 120 with septic shock (6.2%). For this sample, the mean age was 62 ± 20, SAPS3 was 71 ± 18, 55.8% were males, and the hospital mortality was 49% (n = 59). In the NSG group, there was a higher incidence of decreased level of consciousness (83.1% vs. 52.5%, P = 0.00), acute respiratory failure (96.6% vs. 83.6%, P = 0.03), hypocapnia (60.8% vs. 39.2%, P = 0.02), acidemia (77.4% vs. 50%, P = 0.01), need for invasive mechanical ventilation (83.1% vs. 45.9%, P = 0.00), and thrombocytopenia <60,000/mm3 (25.4% vs. 4.9%, P = 0.00). There was no difference between the groups regarding age (64 ± 21 vs. 61 ± 18, P = 0.37), PaO2/FiO2 ratio (174 ± 129 vs. 250 ± 236, P = 0.07), gender (47.5% vs. 63.9%, P = 0.37), incidence of acute renal injury (47.5% vs. 32.8%, P = 0.14), and arterial lactate (2.1 ± 1.1 vs. 1.8 ± 1.0, P = 0.13). The NSG group had greater SAPS3 score (82 ± 14 vs. 60 ± 15, P = 0.00). After logistic regression, only decreased level of consciousness (P = 0.00) and need for invasive mechanical ventilation (P = 0.01) were independently associated with hospital mortality.
In patients with septic shock, decreased level of consciousness and need for invasive mechanical ventilation were independently associated with hospital mortality.
Amorim FF, Santana AR, Biondi RS, Amorim AP, Moura EB, Quadros KJ, Oliveira HS, Ribeiro RA: Difference in patient outcomes coming from public and private hospitals in an intensive care unit in Brazil. J Clin Med Res. 2012, 4: 410-414.
Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001, 345: 1368-1377. 10.1056/NEJMoa010307.
About this article
Cite this article
Menezes, B.M., Araújo, F.V.B., Amorim, F.F. et al. Prognostic factors in the first hour post admission for intra-hospital mortality in patients with septic shock in an ICU. Crit Care 17, P49 (2013). https://doi.org/10.1186/cc12949
- Septic Shock
- Respiratory Failure
- Severe Sepsis
- Hospital Mortality
- Renal Injury