Predictors of mortality in patients with severe sepsis admitted to an ICU
- Fernanda Vilas Bôas Araújo1,
- Fábio Ferreira Amorim1,
- Adriell Ramalho Santana1,
- Felipe Bozi Soares1,
- Bárbara Magalhães Menezes1,
- Jacqueline Lima de Souza1,
- Mariana Pinheiro Barbosa de Araújo1,
- Louise Cristhine de Carvalho Santos1,
- Pedro Henrique Gomes Rocha1,
- Lucas Garcia de Souza Godoy1,
- Kátia Crys Moura Ogliari1,
- Pedro Nery Ferreira Júnior1,
- Alethea Patrícia Pontes Amorim2,
- Rodrigo Santos Biondi3 and
- Rubens Antônio Bento Ribeiro3
© Araújo et al.; licensee BioMed Central Ltd. 2013
Published: 5 November 2013
Severe sepsis is an important cause of morbidity and mortality for patients in ICUs . Since instituting rapid treatment for patients with sepsis is critical, the need for reliable predictors of mortality to guide therapy is evident. This study attempts to identify the risk factors for mortality in patients admitted with severe sepsis to the ICU.
Materials and methods
Case-control study conducted in the ICU of Hospital Anchieta, Brasília, DF, Brazil, during 5 months. Patients were divided into two groups: survivors group (SG) and nonsurvivors group (NSG).
During the study, 38 patients were admitted with severe sepsis, with a mortality rate of 47% (n = 18). Upon admission, the patients in the NSG presented higher values of: SAPS3 score (82 ± 12 vs. 60 ± 14, P = 0.00), heart rate (119 ± 21 vs. 99 ± 15 bpm, P = 0.00), serum creatinine (2.4 ± 1.4 vs. 1.5 ± 0.9 mg/dl, P = 0.00), decreased level of consciousness (92% vs. 58%, P = 0.03), need for vasopressor (85% vs. 25%, P = 0.00), need for invasive mechanical ventilation (62% vs. 12%, P = 0.00) and previous cardiac arrest (15% vs. 0%, P = 0.00). The platelet count was lower in the NSG (119,000 ± 70,000 vs. 220,000 ± 103.000/mm3, P = 0.00). There was no significant difference between the groups regarding the following factors: age (65 ± 19 vs. 65 ± 19 years, P = 0.98), respiratory rate (29 ± 9 vs. 26 ± 7 rpm, P = 0.30), axillary temperature (36.9 ± 0.7 vs. 37.2 ± 1.8°C, P = 0.43), leukocyte count (17,500 ± 7,800 vs. 13,000 ± 6.000/mm3, P = 0.08), immunosuppression (38.5% vs. 12.5%, P = 0.07), and prior use of corticosteroids (23% vs. 25%, P = 0.90).
SAPS3 score, metastatic cancer, decreased level of consciousness, need for vasopressors, invasive mechanical ventilation, previous cardiac arrest, heart rate, serum creatinine, and platelet count were associated with mortality in severe sepsis for this sample of patients.
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