Fungal disease in AIDS patients in intensive care
© Santos et al.; licensee BioMed Central Ltd. 2013
Published: 5 November 2013
Information about the prevalence of fungal diseases in critically ill AIDS patients is sparse. Our goal is to describe the prevalence of fungal diseases in this population, when they are admitted to the ICU.
Materials and methods
Prospective, observational study. Blood and urine samples were collected from 65 AIDS patients at a specialized ICU in infectious diseases, from August 2011 to June 2013. When indicated by clinical suspicion, samples of respiratory, bone marrow and/or tissue were collected. Cultures, cytopathology and serologic tests were performed to evaluate fungal colonization or infection. Clinical data were collected from medical records. Values are expressed as the median and percentage.
No fungal (n= 48)
Fungal (n= 17)
38 (31 to 43)
35 (33 to 46)
CD4+ lymphocyte count (cell/mm3)
69 (32 to 204)
28 (14 to 115)
Nadir CD4+ (cell/mm3)
57 (27 to 153)
27 (14 to 122)
Time since HIV diagnosis (months)
31 (1 to 123)
13 (1 to 77)
One in four HIV/AIDS critically ill patients presents with fungal disease when they are admitted to the ICU. Surveillance of fungal pathogens shall be necessary in the first screening of medical HIV/AIDS patients in the ICU.
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