Skip to main content

Moving beyond the 'pancreatic rest' in severe and critical acute pancreatitis


Nasojejunal tube feeding is considered the current standard of care in patients with severe and critical acute pancreatitis. However, it is not known whether enteral nutrition is best delivered into the jejunum. This Commentary discusses recent clinical studies that have shown that tube feeding into the stomach is safe and well tolerated in the vast majority of patients with acute pancreatitis, thus overthrowing the notion of putting the pancreas at rest. Development of a new conceptual framework is warranted to further advance nutritional management of patients with acute pancreatitis.

Enteral nutrition is a rapidly evolving frontier in the management of acute pancreatitis (AP). In the previous issue of Critical Care, Chang and colleagues investigate whether nasojejunal tube feeding confers any tangible benefit compared with nasogastric tube feeding in patients with AP [1]. It has been 5 years since publication of the previous systematic review on the topic [2] and it is timely to review the progress. Further, the recent international multidisciplinary classification of AP has redefined the 'severe' category of severity and introduced the new 'critical' category of severity (Table 1), thus putting a high emphasis on the need to optimise management of these most challenging patients [36].

Table 1 Definitions of the four severity categories according to the 2012 international multidisciplinary classification of acute pancreatitis [4]

The study by Chang and colleagues [1] adds an important perspective to the discussion regarding the 'pancreatic rest' concept, which is perhaps the oldest dogma in the management of AP. The central tenet of this concept is that enteral nutrition delivered into any part of the upper gastrointestinal tract other than the jejunum stimulates pancreatic secretion and, consequently, exacerbates the severity of AP. The corollary is that 'non-stimulatory' nutrition had been widely advocated, being total parenteral nutrition two to three decades ago and nasojejunal tube feeding in the past decade. That is why the majority of randomised controlled trials in the past studied 'non-stimulatory' regimens as both intervention and comparator, that is, either parenteral nutrition versus nil per os, or parenteral nutrition versus jejunal tube feeding, or jejunal tube feeding versus nil per os [7, 8]. It is argued that this has retarded progress in the field.

The systematic literature review by Chang and colleagues [1] has appraised the current best evidence regarding the use of nasogastric tube feeding (presumed to be 'stimulatory') in patients with AP. It demonstrates that the evidence base is (still) relatively small but does show that enteral nutrition given via the nasogastric route is well tolerated in more than 90% of patients with AP [911]. In line with the previous systematic review [2], it shows no statistically significant difference between 'non-stimulatory' and 'stimulatory' regimens in terms of morbidity and mortality. The new, and somewhat surprising, finding here is that both routes of enteral feeding appear to be equivalent in terms of delivery of target calories.

There are two possible explanations for the observed results. First, tube feeding into the stomach might have been 'non-stimulatory' in patients with AP. Unfortunately, little is known about the secretory response of the pancreas during the acute phase of clinical AP, let alone the effect of feeding on it [12]. But a study in healthy volunteers demonstrated that both oral and duodenal tube feeding stimulate pancreatic enzyme secretion in comparison with placebo [13]. Moreover, the degree of pancreatic stimulation is very similar between oral and duodenal tube feeding. Second, tube feeding into the stomach might have stimulated the pancreas in patients with AP but it has no clinical ramifications, essentially meaning that the concept of 'pancreatic rest' might have been fallacious. Although it has become deeply entrenched in the management of AP, it is worth noting that the 'pancreatic rest' concept was never proven in randomised controlled trials. Moreover, the recent MIMOSA (MIld to MOderate acute pancreatitis: early naSogastric tube feeding compared with pAncreatic rest) trial compared in a randomized fashion early nasogastric tube feeding (commenced within 24 hours after hospital admission) with nil per os and found that nasogasric feeding does not exacerbate the course of AP and even reduces the risk of oral food intolerance [14]. Similarly, an earlier randomised controlled trial compared early nasogastric tube feeding (commenced within 24 hours after hospital admission) with parenteral nutrition and found no difference between 'non-stimulatory' and 'stimulatory' regimens [15].

In conclusion, accumulating evidence indicates that the site of enteral tube feeding does not affect major clinical outcomes in patients with AP. Given that tube feeding into the stomach is more practical than into the jejunum in the majority of clinical settings, it should be considered as the first-line approach for patients with severe and critical AP. The 'pancreatic rest' concept can now be put to rest. There is a need and justification for developing a contemporary conceptual framework concerning nutritional management of AP.



acute pancreatitis.


  1. 1.

    Chang Y, Fu H, Xiao Y, Liu J: Nasogastric or nasojejunal feeding in predicted severe acute pancreatitis: a meta-analysis. Crit Care. 2013, 17: R118-10.1186/cc12790.

    PubMed  PubMed Central  Article  Google Scholar 

  2. 2.

    Petrov MS, Correia MI, Windsor JA: Nasogastric tube feeding in predicted severe acute pancreatitis. A systematic review of the literature to determine safety and tolerance. JOP. 2008, 9: 440-448.

    PubMed  Google Scholar 

  3. 3.

    Petrov MS, Windsor JA: Conceptual framework for classifying the severity of acute pancreatitis. Clin Res Hepatol Gastroenterol. 2012, 36: 341-344. 10.1016/j.clinre.2012.02.010.

    PubMed  Article  Google Scholar 

  4. 4.

    Dellinger EP, Forsmark CE, Layer P, Lévy P, Maraví-Poma E, Petrov MS, Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA, Pancreatitis Across Nations Clinical Research and Education Alliance (PANCREA): Determinant-based classification of acute pancreatitis severity: An international multidisciplinary consultation. Ann Surg. 2012, 256: 875-880. 10.1097/SLA.0b013e318256f778.

    PubMed  Article  Google Scholar 

  5. 5.

    Petrov MS, Windsor JA, Lévy P, Pancreatitis Across Nations Clinical Research and Education Alliance (PANCREA): New international classification of acute pancreatitis: more than just 4 categories of severity. Pancreas. 2013, 42: 389-391. 10.1097/MPA.0b013e3182880513.

    PubMed  Article  Google Scholar 

  6. 6.

    Maraví Poma E, Zubia Olascoaga F, Petrov MS, Navarro Soto S, Laplaza Santos C, Morales Alava F, Darnell Martin A, Gorraiz López B, Bolado Concejo F, Casi Villarroya M, Aizcorbe Garralda M, Albeniz Arbizu E, Sánchez-Izquierdo Riera JA, Tirapu León JP, Bordejé Laguna L, López Camps V, Marcos Neira P, Regidor Sanz E, Jiménez Mendioroz F: SEMICYUC 2012. Recommendations for intensive care management of acute pancreatitis. Med Intensiva. 2013, 37: 163-179. 10.1016/j.medin.2013.01.007.

    PubMed  Article  Google Scholar 

  7. 7.

    Petrov MS, Pylypchuk RD, Emelyanov NV: Systematic review: nutritional support in acute pancreatitis. Alim Pharmacol Ther. 2008, 28: 704-712. 10.1111/j.1365-2036.2008.03786.x.

    CAS  Article  Google Scholar 

  8. 8.

    Petrov MS, Loveday BP, Pylypchuk RD, McIlroy K, Phillips AR, Windsor JA: Systematic review and meta-analysis of enteral nutrition formulations in acute pancreatitis. Br J Surg. 2009, 96: 1243-1252. 10.1002/bjs.6862.

    PubMed  CAS  Article  Google Scholar 

  9. 9.

    Eatock FC, Chong P, Menezes N, Murray L, McKay CJ, Carter CR, Imrie CW: A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol. 2005, 100: 432-439. 10.1111/j.1572-0241.2005.40587.x.

    PubMed  CAS  Article  Google Scholar 

  10. 10.

    Kumar A, Singh N, Prakash S, Saraya A, Joshi YK: Early enteral nutrition in severe acute pancreatitis: a prospective randomized controlled trial comparing nasojejunal and nasogastric routes. J Clin Gastroenterol. 2006, 40: 431-434. 10.1097/00004836-200605000-00013.

    PubMed  CAS  Article  Google Scholar 

  11. 11.

    Singh N, Sharma B, Sharma M, Sachdev V, Bhardwaj P, Mani K, Joshi YK, Saraya A: Evaluation of early enteral feeding through nasogastric and nasojejunal tube in severe acute pancreatitis: a noninferiority randomized controlled trial. Pancreas. 2012, 41: 153-159. 10.1097/MPA.0b013e318221c4a8.

    PubMed  Article  Google Scholar 

  12. 12.

    Dominguez-Munoz JE, Pieramico O, Buchler M, Malfertheiner P: Exocrine pancreatic function in the early phase of human acute pancreatitis. Scand J Gastroenterol. 1995, 30: 186-191. 10.3109/00365529509093260.

    PubMed  CAS  Article  Google Scholar 

  13. 13.

    O'Keefe SJ, Lee RB, Anderson FP, Gennings C, Abou-Assi S, Clore J, Heuman D, Chey W: Physiological effects of enteral and parenteral feeding on pancreaticobiliary secretion in humans. Am J Physiol Gastrointest Liver Physiol. 2003, 284: G27-G36.

    PubMed  Article  Google Scholar 

  14. 14.

    Petrov MS, McIlroy K, Grayson L, Phillips AR, Windsor JA: Early nasogastric tube feeding versus nil per os in mild to moderate acute pancreatitis: A randomized controlled trial. Clin Nutr. 2012

    Google Scholar 

  15. 15.

    Eckerwall GE, Axelsson JB, Andersson RG: Early nasogastric feeding in predicted severe acute pancreatitis: A clinical, randomized study. Ann Surg. 2006, 244: 959-965. 10.1097/01.sla.0000246866.01930.58.

    PubMed  PubMed Central  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Maxim S Petrov.

Additional information

Competing interests

The author declares that they have no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Petrov, M.S. Moving beyond the 'pancreatic rest' in severe and critical acute pancreatitis. Crit Care 17, 161 (2013).

Download citation


  • Acute Pancreatitis
  • Parenteral Nutrition
  • Acute Pancreatitis
  • Enteral Nutrition
  • Tube Feeding