Serum C-reactive protein concentration in early abdominal and pulmonary sepsis
Critical Care volume 17, Article number: P53 (2013)
The objective of this study was to evaluate the C-reactive protein serum levels in patients with pulmonary and abdominal sepsis during the first 5 days of sepsis progression.
The present investigation was a retrospective cohort study conducted at the university hospital with 345 patients who were admitted to the ICU and diagnosed with sepsis of pulmonary or abdominal origin. Serum C-reactive protein concentrations were measured by the turbidimetric immunoassay. For analysis of C-reactive protein, day 1 was defined as the day on which the patient was clinically diagnosed with sepsis.
Thirty-four patients with sepsis (9.8%), 114 patients with severe sepsis (33.0%), and 197 patients with septic shock (57.2%) were evaluated. The age of the patients was 56.4 ± 19.8 years. The serum C-reactive protein concentrations were higher on the day of sepsis diagnosis in the group with abdominal infection compared with the group with pulmonary sepsis (17.8 ± 10.1 mg/dl vs. 14.9 ± 11.1 mg/ dl, P = 0.025) and remained significantly higher during the first 5 days of sepsis progression. The values of the area under the ROC curve, sensitivity, specificity, and best cutoff points are listed in Table 1.
The accuracy of C-reactive protein for the differential diagnosis of pulmonary and abdominal sepsis is limited, although significantly higher serum levels were observed in patients with abdominal sepsis.
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Orati, J., Lobo, S. Serum C-reactive protein concentration in early abdominal and pulmonary sepsis. Crit Care 17 (Suppl 3), P53 (2013). https://doi.org/10.1186/cc12669