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Fluid responsiveness in pressure support ventilation: role of asynchrony


Pulse pressure variation (PPV) is a dynamic indicator of fluid responsiveness, which is known to have a low sensibility and specificity in patients ventilated in pressure support (PS) [1]. We aim to investigate patient-ventilator asynchrony as a potential source of hemodynamic interference in PS.


We performed a prospective study including PS ventilated patients who met inclusion criteria for fluid depletion [1]. Patients who showed an asynchrony index (AI) exceeding 10% were included in the asynchrony group (AG). The remaining patients were included in the synchrony group (SG) [2]. Beat-to-beat hemodynamic variables were recorded through PRAM (Mostcare; Vytech Health srl, Padova, Italy). PPV cutoff of 13% was used to identify fluid responders/nonresponders. A fluid challenge of 500 ml normal saline was given in 5 minutes. An increase of 15% of cardiac index after 10 minutes indicated fluid responsiveness.


So far, eights patients showed an AI >10% while 16 did not. Overall sensitivity was 28.6% versus 50% in SG; overall specificity was 76.5% versus 91.7% in AG. Overall Cohen's k was 33.3% versus 61.2% in AG (see Figure 1). However, because none of the responders in the AG group was detected by PPV, statistical analysis was not feasible within this subgroup

Figure 1



The consistency of PPV in predicting fluid responsiveness during PS seems to be more reliable in the patients with better patient-ventilator synchrony.


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Correspondence to A Messina.

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Messina, A., Colombo, D., Cammarota, G. et al. Fluid responsiveness in pressure support ventilation: role of asynchrony. Crit Care 17, P202 (2013).

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  • Emergency Medicine
  • Normal Saline
  • Cardiac Index
  • Support Ventilation
  • Pressure Support