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Hospital-acquired bloodstream infection: Indian perspective

Introduction

This is a 1-year prospective study to determine the incidence, source and etiology of hospital-acquired bloodstream infection (HABSI) in the Indian context. The resistance pattern was also reviewed.

Methods

A single-centre prospective study in a 35-bed ICU. HABSI was defined according to current CDC guidelines. HCAP, catheter-associated UTI (CAUTI) and skin-related infections causing BSI was also defined according to recent guidelines and analysed.

Results

Out of 332 positive samples, 90 samples (n = 45) were HABSI. The microbiological analysis showed 60% were Gram-negative, 6% were candida and 27% were Gram-positive. The commonest isolate was klebsiella and MRSA was commonest in Gram-positive. The source of HABSI showed CRBSI was the commonest cause at 69%, which correlates with international data. Ventilator-associated pneumonia and CAUTI caused 9.5% BSI respectively. The resistance pattern among Gram-negative bacteria showed multidrug-resistant (MDR) and extreme drug-resistant (XDR) isolates were highest. See Tables 1 and 2.

Table 1 Source
Table 2 Resistance pattern

Conclusion

The incidence of HABSI is 27%. Of this, CRBSI cause 70% and Gram-negative bacteria were commonest with high resistance. This is in contrast to western data where Gram-positive infections are common. Our study highlights need for stringent guidelines for CRBSI prevention.

References

  1. 1.

    Richard , et al.: Crit Care Med. 1999, 27: 887-892. 10.1097/00003246-199905000-00020

  2. 2.

    Valles , et al.: J Infect. 2008, 56: 27-34. 10.1016/j.jinf.2007.10.001

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Author information

Correspondence to R Agrawal.

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Agrawal, R., Varma, A. Hospital-acquired bloodstream infection: Indian perspective. Crit Care 17, P48 (2013). https://doi.org/10.1186/cc11986

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Keywords

  • Resistance Pattern
  • Microbiological Analysis
  • International Data
  • Recent Guideline
  • Indian Context