- Poster presentation
- Open Access
Estimation of efficacy early selective LPS sorption in patients with septic shock
© Kulabukhov et al.; licensee BioMed Central Ltd. 2012
- Published: 14 November 2012
- Septic Shock
- Early Initiation
- Oxygenation Index
- Recent Improvement
Recent improvements in the treatment of severe Gram-negative sepsis have not resulted in a substantial decrease in mortality. LPS, originating from Gram-negative bacteria, is a major mediator in the development of septic shock . Decreasing the load of LPS in these patients may be beneficial for these patients. The Alteco LPS Adsorber® selectively binds the lipid A moiety of LPS. Positive effects of the adsorber have been reported [2–4].
Nineteen patients with Gram-negative sepsis were treated with the Alteco LPS Adsorber®, in addition to standard therapy according to SSC Guidelines 2008. All patients needed inotropic support and mechanical lung ventilation. The mean APACHE II score at the start of treatment was 25.9 ± 1.8. The time to initiating the perfusion varied between 1.7 and 8.6 hours after the diagnosis of septic shock. The treatment lasted 120 minutes and was repeated after 24 hours. The SOFA score, oxygenation index (PaO2/FiO2) and the dose of dopamine was noted before and 48 hours after the treatment.
Since LPS is a major mediator in Gram-negative sepsis, there is a rationale for rapid removal of LPS from patients with sepsis. Early initiation of LPS adsorption is most effective for reducing the signs of MODS. Our experiences with the use of Alteco LPS Adsorber® are promising as shown by our data above and are in support of previous findings [2–4]. The results are limited by the lack of controls; however, we believe that further randomized controlled clinical studies using this therapy are warranted, more so in view of the fact that no specific treatment against septic shock is available.
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