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Effects of sesamol against acute kidney injury in cecal-ligation-and-puncture-treated rats
Critical Care volume 16, Article number: P70 (2012)
Methods
Rats were given two subcutaneous doses of sesamol (10 mg/kg) 0 and 6 hours after CLP. Serum and kidney tissue were sampled 12 hours after CLP. Renal function and proinflammatory mediators, such as IL-1β, IL-6, and nitrite production were detected. Systemic oxidative stress was assessed by determining nitric oxide, superoxide anion, and xanthine oxidase activities. In addition, inducible nitric oxide synthase (iNOS) expression was also assessed in leukocytes from rats with AKI.
Results
The levels of serum BUN, CRE, IL-1β, IL-6, nitrite, iNOS expression, superoxide anion, and xanthine oxidase activity were significantly higher in rats after CLP. Sesamol significantly inhibited all parameters in CLP-treated rats.
Conclusion
Sesamol attenuated AKI by inhibiting neutrophil-initiated systemic inflammation and oxidative stress in CLP-treated rats.
References
Leithead JA, Ferguson JW, Bates CM, Davidson JS, Lee A, Bathgate AJ, Hayes PC, Simpson KJ: The systemic inflammatory response syndrome is predictive of renal dysfunction in patients with non-paracetamol-induced acute liver failure. Gut 2009, 58: 443-449. 10.1136/gut.2008.154120
Li YH, Hsu DZ, Liu MY: Sesamol attenuates systemic inflammation-associated acute kidney injury in polymicrobial infectious rats. In Science Against Microbial Pathogens: Communicating Current Research and Technological Advances. Edited by: Mendez-Vilas A. Badajoz, Spain: Formatex Research Center; 2011:504-510.
Acknowledgements
This study was supported by grants from the National Science Council, Taiwan.
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Chien, S., Li, Y. & Liu, M. Effects of sesamol against acute kidney injury in cecal-ligation-and-puncture-treated rats. Crit Care 16 (Suppl 3), P70 (2012). https://doi.org/10.1186/cc11757
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DOI: https://doi.org/10.1186/cc11757