Volume 16 Supplement 3

Sepsis 2012

Open Access

Effects of sesamol against acute kidney injury in cecal-ligation-and-puncture-treated rats

  • S Chien1,
  • Y Li2 and
  • M Liu2
Critical Care201216(Suppl 3):P70


Published: 14 November 2012


Polymicrobial infection is associated with systemic inflammatory response, which is involved in the pathogenesis and development of acute kidney injury (AKI) [1, 2]. In this study, we examined the effect of sesamol against AKI in cecal-ligation-and-puncture (CLP)-treated rats.


Rats were given two subcutaneous doses of sesamol (10 mg/kg) 0 and 6 hours after CLP. Serum and kidney tissue were sampled 12 hours after CLP. Renal function and proinflammatory mediators, such as IL-1β, IL-6, and nitrite production were detected. Systemic oxidative stress was assessed by determining nitric oxide, superoxide anion, and xanthine oxidase activities. In addition, inducible nitric oxide synthase (iNOS) expression was also assessed in leukocytes from rats with AKI.


The levels of serum BUN, CRE, IL-1β, IL-6, nitrite, iNOS expression, superoxide anion, and xanthine oxidase activity were significantly higher in rats after CLP. Sesamol significantly inhibited all parameters in CLP-treated rats.


Sesamol attenuated AKI by inhibiting neutrophil-initiated systemic inflammation and oxidative stress in CLP-treated rats.



This study was supported by grants from the National Science Council, Taiwan.

Authors’ Affiliations

Tainan University of Technology
National Cheng Kung University


  1. Leithead JA, Ferguson JW, Bates CM, Davidson JS, Lee A, Bathgate AJ, Hayes PC, Simpson KJ: The systemic inflammatory response syndrome is predictive of renal dysfunction in patients with non-paracetamol-induced acute liver failure. Gut 2009, 58: 443-449. 10.1136/gut.2008.154120View ArticlePubMedGoogle Scholar
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© Chien et al.; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.