Skip to main content

Advertisement

Low dose pentoxifylline (PTX) reduces mortality in an animal model of acute hepatic and multi-organ failure

Introduction

Pentoxifylline inhibits, release of TNF-α, platelet aggregation and adherence of leukocytes to endothelium. Previous studies report increased mortality following its use.

Methods

AHF is induced by two intraperitoneal (i.p.) injections (500 mg/kg 8 hours apart) of TAA. Four groups were studied (n = 5). Group 1 received TAA only. Groups 2, 3, & 4 followed the protocol for Group 1, however, Groups 2 and 3 were pre-treated for 5 days with once daily high dose PTX (300 mg/kg i.p.) and low dose PTX (25 mg/kg i.p.), respectively. Whereas, Group 4, commenced PTX (25 mg/kg i.p.) post-TAA for 5 days. Mortality was determined at 96 hours in separate groups (n = 5).

Results

See Table.

Table 1 Table 1

Conclusion

Pre-treatment with low dose PTX reduces hepatic injury, multi-organ failure and mortality.

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rahman, T., Hodgson, H. Low dose pentoxifylline (PTX) reduces mortality in an animal model of acute hepatic and multi-organ failure. Crit Care 5, P081 (2001). https://doi.org/10.1186/cc1148

Download citation

Keywords

  • Public Health
  • Animal Model
  • Emergency Medicine
  • Platelet Aggregation
  • Separate Group