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Low dose pentoxifylline (PTX) reduces mortality in an animal model of acute hepatic and multi-organ failure
Critical Care volume 5, Article number: P081 (2001)
Pentoxifylline inhibits, release of TNF-α, platelet aggregation and adherence of leukocytes to endothelium. Previous studies report increased mortality following its use.
AHF is induced by two intraperitoneal (i.p.) injections (500 mg/kg 8 hours apart) of TAA. Four groups were studied (n = 5). Group 1 received TAA only. Groups 2, 3, & 4 followed the protocol for Group 1, however, Groups 2 and 3 were pre-treated for 5 days with once daily high dose PTX (300 mg/kg i.p.) and low dose PTX (25 mg/kg i.p.), respectively. Whereas, Group 4, commenced PTX (25 mg/kg i.p.) post-TAA for 5 days. Mortality was determined at 96 hours in separate groups (n = 5).
Pre-treatment with low dose PTX reduces hepatic injury, multi-organ failure and mortality.
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Rahman, T., Hodgson, H. Low dose pentoxifylline (PTX) reduces mortality in an animal model of acute hepatic and multi-organ failure. Crit Care 5, P081 (2001). https://doi.org/10.1186/cc1148
- Public Health
- Animal Model
- Emergency Medicine
- Platelet Aggregation
- Separate Group