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  • Open Access

Post-traumatic rhabdomyolysis: an observational study in seven patients

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Critical Care201216 (Suppl 1) :P458

  • Published:


  • Renal Replacement Therapy
  • Compartment Syndrome
  • Mesenteric Ischemia
  • Crush Injury
  • High Lactate


In the ICU, post-traumatic rhabdomyolysis is a relatively rare (1/5) cause of crush syndrome [1]. Early aggressive treatment is quintessential to avoid complications such as renal failure and death [2]. This observational study intends to assess the incidence of complications after traumatic crush injury in a tertiary trauma center ICU.


During 24 months, seven patients admitted to our surgical intensive care after polytrauma (ISS >15) suffered severe rhabdomyolysis (CPK >5,000 U/l) treated by intensive fluid resuscitation, bicarbonate and furosemide.


The following data are reported in Table 1: renal function (initial creatinine, renal replacement therapy (RRT), rhabdomyolysis (maximal CPK and myoglobin), acidosis (lowest pH, highest lactate (HL), time lactate >5 mmol/l) and complications (mortality, neurological sequelae).
Table 1


Initial creatinine (μmol/l)

69 to 198



Maximal CPK (103 U/l)

11 to 144

Maximal myoglobin (103 U/l)

4 to 159


7 to 7.3

Highest lactate (mmol/l)

2 to 28

Time lactate >5 mmol/l (hours)

0 to 84



Neurological sequelae



Survival was 100% but neurological impairment in the limbs is a major complication. The two RRT patients had a wide range of maximal CPK levels (15,780 to 52,600 U/l), but more severe acidosis (lowest pH 7.0 to 7.2, maximum lactate: 7.5 to 28 mmol/l, acidosis duration: 72 to 84 hours). This acidosis turned out to be due to intra-abdominal complications: post-traumatic pancreatitis and mesenteric ischemia. The vital prognosis of post-traumatic crush injury was good but the sequelae of the compartment syndrome were major. The need for RRT was not linked to CPK levels but rather to acidosis due to intra-abdominal complications.

Authors’ Affiliations

réanimation chirurgicale, Strasbourg, France


  1. Bagley WH, Yang H, Shah KH: Rhabdomyolysis. Intern Emerg Med 2007, 2: 210-218. 10.1007/s11739-007-0060-8View ArticlePubMedGoogle Scholar
  2. Bosch X, Poch E, Grau JM: Rhabdomyolysis and acute kidney injury. N Engl J Med 2009, 361: 62-72. 10.1056/NEJMra0801327View ArticlePubMedGoogle Scholar


© Alezrah et al.; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.