Skip to main content

Preoperative diclofenc reduces postcraniotomy headache: a randomized, placebo-controlled trial

Introduction

We tested the hypothesis that 100 mg oral preoperative diclofenac reduces postcraniotomy headache.

Methods

A total of 145 patients having elective craniotonomies were randomly assigned to diclofenac or placebo. Severity of pain was assessed by an independent observer using a visual analogue scale on the day of surgery, on the first postoperative day, and on the fifth postoperative day. The total amount of analgesics administered during the first five postoperative days was converted to intramuscular morphine equivalents. Results were compared using unpaired, two-tailed t tests; P < 0.05 was considered statistically significant.

Results

In total, 104 patients had supratentorial and 41 had infratentorial interventions. Sixty-two patients were assigned to placebo and 83 were assigned to diclofenac. The results of VAS scores are shown in Table 1.

Table 1 Results of VAS scores

The relative efficacy of diclofenac was similar in patients having supratentorial and infratentorial surgery. Diclofenac also appeared to be comparably effective in both men and women. Systemic analgesic requirements were reduced during the initial five postoperative days in patients assigned to diclofenac (intramuscular morphine equivalents: placebo = 5.3 ± 4.3 mg vs. diclofenac = 3.6 ± 3.3 mg).

Conclusion

Preoperatively diclofenac reduces postcraniotomy head-ache compared to placebo, and reduces postoperative analgesic requirements.

Author information

Affiliations

Authors

Corresponding author

Correspondence to C Molnár.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Molnár, C., Simon, É., Gál, J. et al. Preoperative diclofenc reduces postcraniotomy headache: a randomized, placebo-controlled trial. Crit Care 16, P334 (2012). https://doi.org/10.1186/cc10941

Download citation

Keywords

  • Public Health
  • Placebo
  • Morphine
  • Visual Analogue Scale
  • Emergency Medicine