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Volume 16 Supplement 1

32nd International Symposium on Intensive Care and Emergency Medicine

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Left ventriculum diastolic dysfunction in pediatric septic shock

Critical Care volume 16, Article number: P193 (2012) Cite this article

Introduction

One of the causes of septic mortality is a low cardiac output secondary to preload failure. Same patients demonstrate preload failure after aggressive volume replacement [1].

Methods

Ultrasound impulse-wave Doppler evaluation of transmitral flow: VmaxE, VmaxA, ejection time E,A; DT E wave, IVRT of LV. Ultrasound evaluation of end-diastolic and end-systolic LV volume, stroke volume (LVEDV, LVESV, SV) on Teichholz L. EDLVP = 1.06 + 15.15 × VTI peakA/VTI peakE. Coronary perfusion pressure (CPP) = EDLVP - diastolic BP. We evaluate these parameters in 34 patients (age 28.1 ± 8.0 months) with septic shock (SS) diagnosed according to Consensus 2002. Control (C) - 44 healthy children (age 40.7 ± 8.5 months). Statistical analyses with t criteria.

Results

The increase of VmaxA and decrease of VmaxE in patients of SS are demonstrated. IVRT and DT are less than in control group. We evaluated a decrease in E/A proportion. EDLVP in patients was more, and CPP lower, than in controls. See Table 1.

Table 1 Diastolic function in pediatric septic shock
Full size table

Conclusion

Pediatric SS accompanied with LV diastolic dysfunction, which decreases the effectiveness of volume restoration therapy, reduces preload and cardiac output.

References

  1. Jardin F, et al.: Persistent preload defect in severe sepsis despite fluid loading. A longitudinal echocardiographic study in patients with septic shock. Chest 1999, 116: 1354-1359. 10.1378/chest.116.5.1354

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Authors and Affiliations

  1. Kharkov Medical Academy Post-Graduate Education, Kharkov, Ukraine

    M Georgiyants & V Korsunov

Authors
  1. M Georgiyants
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  2. V Korsunov
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Georgiyants, M., Korsunov, V. Left ventriculum diastolic dysfunction in pediatric septic shock. Crit Care 16 (Suppl 1), P193 (2012). https://doi.org/10.1186/cc10800

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Critical Care

ISSN: 1364-8535