- Poster presentation
- Open access
- Published:
Does tight glycemic control positively impact on patient mortality?
Critical Care volume 16, Article number: P176 (2012)
Introduction
High and variable blood glucose (BG) levels have been associated with increased mortality. Tight glycemic control (TGC) aims at reducing BG levels to improve patient outcome and mortality. This research evaluates the impact of TGC on mortality.
Methods
This study used glycemic data from 1,488 patients of two cohorts: Glucontrol (n = 704) and SPRINT (n = 784). TGC glycemic outcome is measured by cumulative time in the 4 to 7 mmol/l band (cTIB), defined daily for each patient. Each day, patients were divided into two groups: cTIB <70% and cTIB ≥70%. For each group, odds of living (OL = #lived/#died) was calculated.
Results
OL for cTIB ≥70% patients tends to increase over time while OL for cTIB <70% patients decreases (Figure 1). On Day 1, OL for cTIB <70% patients and cTIB ≥70% patients are similar (OL = 5.1 and OL = 5.5 respectively). The difference between the two groups increases over the ICU stay. On Day 10, OL = 2.8 and OL = 10.5 for cTIB <70% and cTIB ≥70% patients respectively. These results suggest that survival rate is higher when cTIB ≥70% and thus when BG levels are tightly controlled around normoglycemia. The longer patients' ICU stay, the lower survival rate they have when cTIB <70%.
Whole-cohort odds of living over ICU stay.
Conclusion
Results show that, irrespective of TGC protocols, high cTIB and thus normoglycemia are associated with higher odds of living. This suggests that TGC positively influences patient outcome.
Author information
Authors and Affiliations
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Penning, S., Le Compte, A., Signal, M. et al. Does tight glycemic control positively impact on patient mortality?. Crit Care 16 (Suppl 1), P176 (2012). https://doi.org/10.1186/cc10783
Published:
DOI: https://doi.org/10.1186/cc10783