- Poster presentation
- Open access
- Published:
Impact of blood glucose on blood lactate levels in a medical ICU: a retrospective cohort study
Critical Care volume 16, Article number: P165 (2012)
Introduction
Although blood lactate and glucose both represent important markers in the intensive care setting, they have been considered quite independently. Especially, the ideal glucose target range has been the topic of recent studies with conflicting results [1, 2]. Blood lactate is an acknowledged predictor of outcome in critically ill patients [3]. The aim of this study was to establish a possible correlation between elevated blood glucose and lactate levels in intensive care patients.
Methods
Blood gas data of 1,170 patients, admitted to the medical ICU of the Department of Medicine III, Medical University Vienna, between the years 2001 and 2009, were analysed retrospectively. The association of circulating blood glucose levels with corresponding lactate levels was investigated using a linear regression model. The impact of different blood glucose intervals (<80, 80 to 120, 120 to 160, 160 to 200, >200 mg/dl) on blood lactate levels was analysed using ANOVA. The influence of blood glucose variability, expressed as the blood glucose standard deviation, on mean lactate concentrations for the period of ICU stay was analysed using a linear regression model. To adjust for the severity of illness, a multivariate regression analysis was conducted including SAPS II and APACHE II scores.
Results
Blood glucose and lactate presented a U-shaped curve with a minimum blood lactate (1.5 mmol/l) between 80 and 120 mg/dl blood glucose. ANOVA and linear regression demonstrated a significant influence of blood glucose and blood glucose variability on blood lactate (P = 0.0001). The identification of this relation was supported by the result of a multivariate regression analysis, adjusting for severity of illness (P = 0.0001).
Conclusion
The results demonstrate an influence of blood glucose and blood glucose variability on blood lactate, independent of severity of illness, in a medical ICU patient population.
References
van den Berghe G, et al.: Intensive insulin therapy in the critically ill patients. N Engl J Med 2001, 345: 1359-1367. 10.1056/NEJMoa011300
Finfer S, et al.: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009, 360: 1283-1297.
Khosravani H, et al.: Occurrence and adverse effect on outcome of hyperlactatemia in the critically ill. Crit Care 2009, 13: R90. 10.1186/cc7918
Author information
Authors and Affiliations
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Adelsmayr, G., Brunner, R. & Holzinger, U. Impact of blood glucose on blood lactate levels in a medical ICU: a retrospective cohort study. Crit Care 16 (Suppl 1), P165 (2012). https://doi.org/10.1186/cc10772
Published:
DOI: https://doi.org/10.1186/cc10772