Oxygenation correlates with lung aeration during unsupported spontaneous breathing in porcine lung collapse model
© Vimlati et al.; licensee BioMed Central Ltd. 2012
Published: 20 March 2012
We investigated whether oxygenation correlates with lung aeration during unsupported spontaneous breathing (SB) and mechanical ventilation (MV) in a porcine lung collapse model.
In 14 anesthetized supine piglets, lung collapse was induced by negative pressure application (NPA) to the endotracheal tube. Eight animals resumed SB 5 minutes after NPA, six animals were kept on MV at a respiratory rate and tidal volume corresponding to SB. Thoracic CTs and arterial blood gases were taken 2.5 and 30 minutes after NPA. Spearman rank correlation was used for testing; values are given as mean (95% CI).
In porcine lung collapse PaO2/FiO2 correlates with lung aeration during unsupported SB, but not during MV at a similar breathing pattern. The less lung collapse the animals have, the more PaO2/FiO2 improves resuming SB.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.