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Early application of high-frequency oscillatory ventilation in H1N1 influenza-related severe ARDS is associated with better outcome


High-frequency oscillatory ventilation (HFOV) is a promising rescue modality for refractory hypoxia and was used extensively in H1N1 influenza-related ARDS in 2009 and 2010. The aim of this study was to find predictors of successful outcome of HFOV in H1N1 influenza-related severe ARDS [1].


Patients with H1N1 influenza-related severe ARDS by the new Berlin definition (applied retrospectively) receiving volume-controlled ventilation (VCV) as per the ARDSnet protocol with PO2/FiO2 ≤100 at PEEP ≥12 cmH2O and FiO2 ≥0.7 were connected to HFOV as a rescue therapy for refractory hypoxia. All patients were followed until discharge from the hospital (survivors) or death (nonsurvivors).


About 80 parameters were evaluated as outcome predictors of HFOV like demographics, comorbidities, clinical features, laboratory parameters, X-rays, ventilatory and blood gas parameters and therapy-related complications. Previously collected data of 19 patients were analysed applying the new Berlin definition. Demographic, clinical, comorbidity, laboratory and radiological parameters were comparable in survivors and nonsurvivors. Table 1 shows comparison of survivors and nonsurvivors with respect mainly to ventilatory and gas exchange parameters before application of HFOV. Duration of conventional mechanical ventilation before HFOV, 1.4 ± 0.69 versus 3.66 ± 3.53 days (P = 0.03), was the only discriminating parameter between survivors and nonsurvivors.

Table 1 Comparison of survivors and nonsurvivors


In H1N1 influenza-related severe ARDS, early application of HFOV is a significant predictor of successful outcome.


  1. 1.

    European Society of Intensive Care Medicine: Conference Proceedings of 24th Annual Conference of ESICM, Berlin.

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Correspondence to S Jog.

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Jog, S., Patel, M. & Patel, D. Early application of high-frequency oscillatory ventilation in H1N1 influenza-related severe ARDS is associated with better outcome. Crit Care 16, P111 (2012).

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  • Mechanical Ventilation
  • Successful Outcome
  • Exchange Parameter
  • Rescue Therapy
  • Outcome Predictor