Early application of high-frequency oscillatory ventilation in H1N1 influenza-related severe ARDS is associated with better outcome
© Jog et al.; licensee BioMed Central Ltd. 2012
Published: 20 March 2012
High-frequency oscillatory ventilation (HFOV) is a promising rescue modality for refractory hypoxia and was used extensively in H1N1 influenza-related ARDS in 2009 and 2010. The aim of this study was to find predictors of successful outcome of HFOV in H1N1 influenza-related severe ARDS .
Patients with H1N1 influenza-related severe ARDS by the new Berlin definition (applied retrospectively) receiving volume-controlled ventilation (VCV) as per the ARDSnet protocol with PO2/FiO2 ≤100 at PEEP ≥12 cmH2O and FiO2 ≥0.7 were connected to HFOV as a rescue therapy for refractory hypoxia. All patients were followed until discharge from the hospital (survivors) or death (nonsurvivors).
Comparison of survivors and nonsurvivors
13.3 ± 1.7
13.2 ± 2.2
1.4 ± 0.69
3.66 ± 3.5
35.6 ± 7.1
35.2 ± 5.1
13.4 ± 2.0
13.4 ± 2.8
82.6 ± 31
68.8 ± 34
36.08 ± 24
25.32 ± 7
In H1N1 influenza-related severe ARDS, early application of HFOV is a significant predictor of successful outcome.
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