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Open Access

Early application of high-frequency oscillatory ventilation in H1N1 influenza-related severe ARDS is associated with better outcome

  • S Jog1,
  • M Patel1 and
  • D Patel1
Critical Care201216(Suppl 1):P111

https://doi.org/10.1186/cc10718

Published: 20 March 2012

Keywords

Mechanical VentilationSuccessful OutcomeExchange ParameterRescue TherapyOutcome Predictor

Introduction

High-frequency oscillatory ventilation (HFOV) is a promising rescue modality for refractory hypoxia and was used extensively in H1N1 influenza-related ARDS in 2009 and 2010. The aim of this study was to find predictors of successful outcome of HFOV in H1N1 influenza-related severe ARDS [1].

Methods

Patients with H1N1 influenza-related severe ARDS by the new Berlin definition (applied retrospectively) receiving volume-controlled ventilation (VCV) as per the ARDSnet protocol with PO2/FiO2 ≤100 at PEEP ≥12 cmH2O and FiO2 ≥0.7 were connected to HFOV as a rescue therapy for refractory hypoxia. All patients were followed until discharge from the hospital (survivors) or death (nonsurvivors).

Results

About 80 parameters were evaluated as outcome predictors of HFOV like demographics, comorbidities, clinical features, laboratory parameters, X-rays, ventilatory and blood gas parameters and therapy-related complications. Previously collected data of 19 patients were analysed applying the new Berlin definition. Demographic, clinical, comorbidity, laboratory and radiological parameters were comparable in survivors and nonsurvivors. Table 1 shows comparison of survivors and nonsurvivors with respect mainly to ventilatory and gas exchange parameters before application of HFOV. Duration of conventional mechanical ventilation before HFOV, 1.4 ± 0.69 versus 3.66 ± 3.53 days (P = 0.03), was the only discriminating parameter between survivors and nonsurvivors.
Table 1

Comparison of survivors and nonsurvivors

Variable

Survivors

Nonsurvivors

P value

APACHE

13.3 ± 1.7

13.2 ± 2.2

0.14

Time VCV

1.4 ± 0.69

3.66 ± 3.5

0.03

PIP

35.6 ± 7.1

35.2 ± 5.1

0.44

PEEP

13.4 ± 2.0

13.4 ± 2.8

0.48

P/F

82.6 ± 31

68.8 ± 34

0.37

OI

36.08 ± 24

25.32 ± 7

0.1

Conclusion

In H1N1 influenza-related severe ARDS, early application of HFOV is a significant predictor of successful outcome.

Authors’ Affiliations

(1)
Deenanath Mangeshkar Hospital and Research Centre, Pune, India

References

  1. European Society of Intensive Care Medicine: Conference Proceedings of 24th Annual Conference of ESICM, Berlin.Google Scholar

Copyright

© Jog et al.; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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