Skip to main content

A new miniaturized extracorporeal membrane oxygenator with integrated rotary blood pump (Ilias): first results in a porcine model of lung injury


Extracorporeal membrane oxygenation (ECMO) is used for most severe acute respiratory distress syndrome cases in specialized centres. However, critically ill patients fulfilling ECMO criteria are often not suitable for transportation and currently available ECMO systems are not designed for emergency use or interhospital transfer. Therefore, a new miniaturized ECMO (Ilias; Figure 1) with only 5 kg weight was developed to reduce filling volume and simplify management.

Figure 1
figure 1

The Ilias prototype.


Acute lung injury was induced with repeated pulmonary saline infusion in 13 pigs until the Horowitz Index was <100 mmHg. Pigs were assigned to the following three groups: group 1 (n = 3), control group, conventional ventilation; group 2 (n = 5), standard venovenous ECMO (Maquet); group 3 (n = 5), Ilias group. Gas exchange, hemodynamics, hemolysis, and coagulation activation were examined over a period of 8 hours.


No device failed during the observation period. Oxygenation increased significantly in both ECMO groups compared to baseline and to control (paO2 from 79 ± 8 before Ilias to 340 ± 108 mmHg and from 61 ± 12 mmHg to 309 ± 59 mmHg in the standard ECMO group). The CO2 elimination by the Ilias reduced arterial paCO2 from 134 ± 25 mmHg at baseline to 53 ± 7 mmHg. Hemodynamic instability, significant activation of the plasmatic coagulation or platelet consumption was not observed. However, hemolyses were significantly higher in the Ilias group compared to the Maquet group.


The Ilias prototype provided excellent gas exchange with hemodynamic stability comparable to a standard ECMO system. Further development and design modifications (optimized rotation speed and surface coating of rotor) are already done and another experiment is projected to reduce hemolysis for clinical application.

Author information

Authors and Affiliations


Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Pilarczyk, K., Heckmann, J., Lyskawa, K. et al. A new miniaturized extracorporeal membrane oxygenator with integrated rotary blood pump (Ilias): first results in a porcine model of lung injury. Crit Care 16, P96 (2012).

Download citation

  • Published:

  • DOI:


  • Acute Lung Injury
  • Extracorporeal Membrane Oxygenation
  • Conventional Ventilation
  • Severe Acute Respiratory Distress Syndrome
  • Platelet Consumption