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Necrotizing pneumonia due to methicillin-sensitive Staphylococcus aureus secreting Panton-Valentine leukocidin: a review of case reports
© Kreienbuehl et al.; licensee BioMed Central Ltd. 2012
- Published: 20 March 2012
- Public Health
- Multivariate Analysis
- Systematic Review
- Young Adult
Community-acquired necrotizing pneumonia caused by Panton-Valentine leukocidin (PVL)-secreting Staphylococcus aureus is a highly lethal infection, which mainly affects healthy children and young adults [1, 2]. This study focuses on necrotizing pneumonia due to methicillin-sensitive S. aureus strains, with the purpose to determine factors associated with outcome.
We performed a systematic review of case reports on PVL-secreting MSSA necrotizing pneumonia and analyzed factors associated with outcome.
Univariate analysis of mortality risk factors
Died (n= 13)
Survived (n= 19)
Univariate analysis OR (95% CI)
9.00 (1.60 to 50.7)
0.09 (0.01 to 0.86)
26.0 (1.30 to 522)
5.06 (0.83 to 30.8)
Influenza-like prodrome may be predictive of adverse outcome and previous skin and soft tissue infection may be associated with improved prognosis.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.