Necrotizing pneumonia due to methicillin-sensitive Staphylococcus aureus secreting Panton-Valentine leukocidin: a review of case reports
© Kreienbuehl et al.; licensee BioMed Central Ltd. 2012
Published: 20 March 2012
Community-acquired necrotizing pneumonia caused by Panton-Valentine leukocidin (PVL)-secreting Staphylococcus aureus is a highly lethal infection, which mainly affects healthy children and young adults [1, 2]. This study focuses on necrotizing pneumonia due to methicillin-sensitive S. aureus strains, with the purpose to determine factors associated with outcome.
We performed a systematic review of case reports on PVL-secreting MSSA necrotizing pneumonia and analyzed factors associated with outcome.
Univariate analysis of mortality risk factors
Died (n= 13)
Survived (n= 19)
Univariate analysis OR (95% CI)
9.00 (1.60 to 50.7)
0.09 (0.01 to 0.86)
26.0 (1.30 to 522)
5.06 (0.83 to 30.8)
Influenza-like prodrome may be predictive of adverse outcome and previous skin and soft tissue infection may be associated with improved prognosis.
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