Table 1 Demographics and clinical characteristics of studied groups
Total (n= 95) | IFIa (n= 16) | No IFI (n= 79) | P | |
|---|---|---|---|---|
Age, median years (range) | 69 (18 to 93) | 74 (53 to 82) | 69 (18 to 93) | 0.12 |
Male sex (%) | 65 (68.4) | 11 (68.8) | 54 (68.4) | 0.97 |
SAPS II, median (range) | 47 (14 to 76) | 49.5 (26 to 74) | 46 (14 to 76) | 0.18 |
SOFA, median (range) | 6 (0 to 16) | 5.5 (0 to 15) | 6 (0 to 16) | 0.33 |
ICU stay, median days (range) | ||||
Before sepsis onset | 7 (6 to 67) | 8.5 (6 to 34) | 7 (6 to 67) | 0.95 |
Overall | 20 (6 to 180) | 28 (7 to 92) | 20 (6 to 180) | 0.24 |
ICU mortality (no.,%) | 23 (24.2) | 6 (37.5) | 17 (21.5) | 0.20 |
Diagnosis on ICU admission (no.,%) Medical Surgical Trauma | 61 (64.2) 12 (12.6) 22 (23.2) | 13 (81.3) 2 (12.5) 1 (6.2) | 48 (60.8) 10 (12.7) 21 (26.6) | 0.12 1 0.11 |
Multifocal Candida colonization (no.,%) | 40 (42.1) | 10 (62.5) | 30 (37.9) | 0.07 |
Abdominal surgery (no.,%) | 11 (11.6) | 2 (12.5) | 9 (11.4) | 1 |
Risk factors (no.,%) | ||||
Mechanical ventilation | 85 (89.5) | 16 (100) | 69 (87.3) | 0.20 |
Central venous catheter | 86 (90.5) | 15 (93.7) | 71 (89.9) | 0.63 |
Broad to spectrum antibiotics | 71 (74.7) | 14 (87.5) | 57 (72.2) | 0.19 |
Total parenteral nutrition | 10 (10.5) | 7 (43.7) | 3 (3.8) | < 0.001 |
Corticosteroids | 8 (8.4) | 3 (18.7) | 5 (6.3) | 0.13 |
Renal replacement therapy | 12 (12.6) | 5 (31.3) | 7 (8.9) | 0.03 |
Underlying diseases (no.,%) | ||||
COPD | 20 (21.1) | 5 (31.2) | 15 (19.9) | 0.27 |
Solid transplants | 1 (1.1) | 1 (6.3) | 0 | 0.17 |
HIV | 1 (1.1) | 1 (6.3) | 0 | 0.17 |
Solid cancer | 12 (12.6) | 3 (18.7) | 9 (11.4) | 0.40 |
Hematological malignancy | 1 (1.1) | 1 (6.3) | 0 | 0.17 |
Cirrhosis | 1 (1.1) | 1 (6.3) | 0 | 0.17 |
Chronic renal failure | 24 (25.3) | 8 (50.0) | 16 (20.3) | 0.02 |
Diabetes | 51 (53.7) | 10 (62.5) | 41 (51.9) | 0.44 |
Clinical condition (no.,%) | ||||
Severe sepsis | 54 (56.8) | 5 (31.2) | 49 (62.0) | 0.02 |
Septic shock | 21 (22.1) | 10 (62.5) | 11 (13.9) | < 0.001 |
Pneumonia | 29 (30.5) | 5 (31.3) | 24 (30.4) | 1 |
Gram-positive bloodstream infectionb | 11 (11.5) | 1 (6.2) | 10 (12.6) | 0.46 |
Gram-negative bloodstream infectionc | 7 (7.4) | 0 | 7 (8.9) | 0.21 |
Other bacterial infectiond | 15 (15.7) | 3 (18.7) | 12 (15.2) | 0.72 |
No. of patients (%) with a: | ||||
Positive BG result | 20 (21.1) | 15 (93.7) | 5 (6.3) | < 0.001 |
CS value ≥3 | 21 (22.1) | 12 (75.0) | 9 (11.4) | < 0.001 |
Colonization index ≥0.5 | 33 (35.1) | 9 (56.3) | 24 (30.4) | 0.04 |