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Table 6 Predictive values of biomarkers for ruling out AKI excluding patients with preoperative CKDa

From: Urine hepcidin has additive value in ruling out cardiopulmonary bypass-associated acute kidney injury: an observational cohort study

Biomarkers AUC-ROC (95% CI) Sensitivity Specificity Cutoff
Urine hepcidin, ng/mL     
   6 hours after CPB start 0.81 (0.67 to 0.96) 62.30% 100.00% >545
   24 hours after CPB start 0.83 (0.74 to 0.92) 79.70% 100.00% >475
Urine hepcidin/urine creatinine, ng/mg     
   6 hours after CPB start 0.87 (0.75 to 0.99) 70.00% 100.00% >2820
   24 hours after CPB start 0.75 (0.57 to 0.94) 76.50% 80.00% >1,762
Plasma hepcidin, ng/mL     
   6 hours after CPB start 0.70 (0.46 to 0.98) 69.00% 80.00% >175
   24 hours after CPB start 0.54 (0.23 to 0.86) N/A N/A N/A
  1. aAKI, acute kidney injury; AUC, area under the curve; ROC, receiver operating characteristic; CKD, chronic kidney disease; CPB; cardiopulmonary bypass; N/A, values not presented for AUC-ROC <0.6. AKI is defined as Risk, Injury, Failure, Loss, End-stage renal disease classification of AKI (RIFLE) class R or worse including serum creatinine increase and urine output decrease.