|
Biomarkers
|
AUC-ROC (95% CI)
|
Sensitivity
|
Specificity
|
Cutoff
|
|---|
|
Urine hepcidin, ng/mL
| | | | |
|
6 hours after CPB start
|
0.81 (0.67 to 0.96)
|
62.30%
|
100.00%
|
>545
|
|
24 hours after CPB start
|
0.83 (0.74 to 0.92)
|
79.70%
|
100.00%
|
>475
|
|
Urine hepcidin/urine creatinine, ng/mg
| | | | |
|
6 hours after CPB start
|
0.87 (0.75 to 0.99)
|
70.00%
|
100.00%
|
>2820
|
|
24 hours after CPB start
|
0.75 (0.57 to 0.94)
|
76.50%
|
80.00%
|
>1,762
|
|
Plasma hepcidin, ng/mL
| | | | |
|
6 hours after CPB start
|
0.70 (0.46 to 0.98)
|
69.00%
|
80.00%
|
>175
|
|
24 hours after CPB start
|
0.54 (0.23 to 0.86)
|
N/A
|
N/A
|
N/A
|
- aAKI, acute kidney injury; AUC, area under the curve; ROC, receiver operating characteristic; CKD, chronic kidney disease; CPB; cardiopulmonary bypass; N/A, values not presented for AUC-ROC <0.6. AKI is defined as Risk, Injury, Failure, Loss, End-stage renal disease classification of AKI (RIFLE) class R or worse including serum creatinine increase and urine output decrease.
