Spontaneous rupture of malarial spleen: two case reports and review of literature

  • Yusuf Yagmur1,

    Affiliated with

    • Ismail Hamdi Kara1,

      Affiliated with

      • Mustafa Aldemir1,

        Affiliated with

        • Hüseyin Büyükbayram1,

          Affiliated with

          • Ibrahim H Tacyildiz1 and

            Affiliated with

            • Celalettin Keles1

              Affiliated with

              Critical Care20004:309

              DOI: 10.1186/cc713

              Received: 26 June 2000

              Accepted: 11 July 2000

              Published: 10 August 2000

              Abstract

              Malaria has long been among the most common diseases in the southeast Anatolia region of Turkey. In 1992, 18676 cases were diagnosed in Turkey, and Diyarbakir city had the highest incidence (4168 cases), followed by SanliUrfa city (3578 cases). Malaria was especially common during 1994 and 1995, with 84 345 and 82 094 cases being diagnosed in these years, respectively. Spontaneous rupture of malarial spleen is rare. We saw two cases during 1998, which are reported herein. Both patients were male, and were receiving chloroquine treatment for an acute attack of malaria. One of the patients had developed abdominal pain and palpitations, followed by fainting. The other patient had abdominal pain and fever. Explorative laparotomy revealed an enlarged spleen in both patients. Splenectomy was performed in both patients. We have identified 15 episodes of spontaneous rupture of the spleen in the English language literature published since 1961. Because of increased travel to endemic areas and resistance to antimalarial drugs, malaria is a major medical problem that is becoming increasingly important to surgeons worldwide. Malaria is a particularly important problem in the southeast Anatolia region of Turkey. Prophylactic precautions should be taken by tourists who travel to this region, especially during the summer.

              malaria prophylactic precautions ruptured spleen

              Introduction

              Involvement of the spleen in malaria that results in splenomegaly renders this organ prone to complications such as rupture [1]. In areas where malaria is endemic, spontaneous rupture of spleen is uncommon. Because of increased travel to endemic areas and resistance to anti-malarial drugs, however, malaria is a major medical problem, which is becoming increasingly important to surgeons worldwide. During the 1980s and 1990s in the USA, the annual number of diagnosed cases of malaria rose by twofold to fourfold that of the preceding decade [2,3]. We report two cases of spontaneous rupture of malarial spleen treated with splenectomy.

              Case reports

              Case 1

              A 56-year-old man presented at hospital with sudden onset of upper abdominal pain, followed by palpitations and fainting. He had been taking chloroquine. In the emergency department he was hypotensive and had pain in the left hypochondrium. Ultrasound showed an enlarged, ruptured spleen and free blood in the abdomen. There was free blood (1500 cm2) in the peritoneal cavity, and a friable, enlarged, ruptured spleen (grade III) was found and removed. Pathological examination revealed that the spleen weighed 950 g and measured 21 × 12 × 7 cm. Gross examination showed the spleen to be dark grey, with capsular tear and subcapsular haematoma on the medial side. Microscopy revealed dilatation of sinuses, increased pigmentation and elevated concentration of macrophages. Thick and thin films revealed the presence of Plasmodium vivax. The patient, much improved, was discharged 6 days after the operation.

              Case 2

              A 32-year-old man was receiving treatment for a duodenal ulcer in the gastroenterology department. He was also receiving chloroquine for malaria. For 4 days of hospitalization he had high-grade fever and immediately became hypotensive, and had abdominal pain. We performed abdominal paracentesis, which demonstrated free blood in the peritoneal cavity. Explorative laparotomy revealed approximately one litre of blood in the peritoneal cavity and an enlarged spleen, measuring almost double its normal size with a tear on the inferior surface (grade II). Splenectomy was performed. The spleen was 1050 g and measured 22 × 15 × 8 cm. Gross examination showed grayish brown discoloured spleen with capsular tears at a few places. Microscopy revealed congestion and dilatation of sinuses, and bleeding areas. P vivax was identified by thick film. The patient was discharged well 11 days after the operation.

              Discussion

              Malaria parasites have been with us throughout human history. They probably originated in Africa (along with humans), and fossils of mosquitoes show that the vectors for malaria have existed for at least 30 million years. Plasmodium parasites are highly specific, with humans as the only vertebrate host and Anopheles mosquitoes as the vectors. This specificity of the parasites also indicates a long and adaptive relationship with humans [4].

              Despite initial success, there was complete failure to eradicate malaria in many countries because of a number of factors. Although technical difficulties such as vector and parasite drug resistance have played a part, failure in this endeavour was probably due to social and political factors that prevented efficient application of control measures [4]. The malaria control operation was criticized for being too much like a military operation, and the lack of explanation given to local populations meant that the control measures received little support, or even opposition [5]. Accurate information on the global incidence of malaria is difficult to obtain because reporting is particularly poor in areas that are known to be highly endemic. The global incidence of malaria is estimated to be nearly 120 million clinical cases each year, with nearly 300 million people carrying the parasite. The vast majority of malaria deaths occur in Africa. Estimates vary greatly; the World Health Organization [6] quoted a figure of 800 000 deaths/year in African children during 1991.

              Malaria is generally endemic in the tropics, with extensions into subtropic regions. Malaria in travellers who arrive by air is now an important cause of death in nonmalarious areas [7], and this is not helped by ignorance or indifference of travellers to prophylactic measures [8].

              Malaria has long been among the most common diseases in the southeast Anatolia region of Turkey. During 1992, 18 676 cases were diagnosed in Turkey, and Diyarbakir city had the highest incidence (4168 cases), followed by SanliUrfa city (3578 cases). The southeast Anatolia region is in upper Mesopotamia, covering Diyarbakir, SanliUrfa, GaziAntep, Adiyaman, Batman, Mardin, Siirt and Sirnak. Malaria was especially common during 1994 and 1995, with 84 345 and 82 094 cases being diagnosed in these years, respectively. However, in 1998 the number of new cases decreased, with 36 842 cases being encountered (Table 1). Proquanil with chloroquine have been advised as the best prophylactic regimen for tourists travelling to the southeast Anatolia region of Turkey between March and November [9].
              Table 1

              Reported cases of malaria in Turkey from 1992 to 1998

               

              Years

              Month

              1992

              1993

              1994

              1995

              1996

              1997

              1998

              January

              90

              82

              570

              1032

              973

              413

              194

              February

              80

              96

              335

              1496

              1456

              732

              492

              March

              204

              253

              1132

              3509

              3328

              1375

              998

              April

              565

              1002

              2942

              5081

              4878

              1897

              1367

              May

              931

              1642

              5557

              6372

              8021

              2996

              2069

              June

              1775

              3261

              12745

              13012

              8846

              4304

              3754

              July

              3186

              6400

              13700

              15228

              10793

              7342

              6817

              August

              3132

              8137

              12033

              12993

              7242

              5890

              6785

              September

              3438

              9391

              13221

              10896

              6656

              5069

              5382

              October

              3030

              9409

              13285

              8796

              5746

              3383

              5045

              November

              1812

              6303

              7006

              2754

              2230

              1533

              2865

              December

              433

              1234

              1819

              927

              715

              522

              1074

              Total

              18676

              47210

              84345

              82096

              60884

              35456

              36842

              Spontaneous rupture of the spleen is well described in many diseases, of which malaria is the most common [10,11]. Other such diseases include infectious mononucleosis, splenic neoplasms and haematological malignancies [1215]. The incidence of rupture of the spleen in malaria is poorly defined. Comparisons of cases that occur in the setting of natural or induced infection have most frequently been employed to investigate this issue. Natural infection is that acquired via a mosquito bite or transpla-centally. Induced infection is that obtained through blood transfusion, sharing of needles, laboratory accidents and experimental or therapeutic inoculation [16]. Fifteen cases of malarial splenic rupture have been reported since 1960 (Table 2). From only three of the reports can the incidence be calculated. Rates of splenic rupture in naturally occurring infection ranged from 0% (0 rupture/5870 total cases of infection) to 2% (1 rupture/51 total cases of infection) [1719]. The only series of splenic ruptures in induced infections reported an incidence of 0.4% (3 ruptures/715 total cases of infection) [19]. That only 15 cases have been reported since 1960 suggests under-reporting or under-diagnosis, especially for those cases of splenic rupture in the setting of naturally acquired infection [1626].
              Table 2

              Reported cases of spontaneous rupture of malarial spleen since 1960

                 

              Long-term resident

                   
               

              Case

               

              of malaria-endemic

              Malarial

               

              Symptoms and

              Surgical

               

              Reference

              no.

              Route

              area

              stage

              Species

              signs

              therapy

              Outcome

              [16]

              1

              Natural

              No

              Chronic

              P malariae

              Shock, Kehr's sign

              Splenectomy

              Lived

                    

              LUQ tenderness

                

              [17]

              2

              Natural

              No

              Acute

              P vivax

              LUQ pain, Kehr's

              Splenectomy

              Lived

                    

              sign

                

              [18]

              3

              Natural

              No

              Acute

              P falciparum

              No material

              No material

              Lived

              [19]

              4

              Induced

              No

              Acute

              P vivax

              Fever, Kehr's sign

              Splenectomy

              Lived

                    

              LUQ tenderness

                
               

              5

              Induced

              No

              Acute

              P vivax

              No material

              Splenectomy

              Lived

               

              6

              Induced

              No

              Acute

              P vivax

              No material

              Splenectomy

              Lived

               

              7

              Induced

              No

              Acute

              P vivax

              No material

              Splenectomy

              Lived

              [20]

              8

              Natural

              No

              Acute

              P falciparum

              Kehr' sign

              Splenectomy

              Lived

                    

              LUQ pain

                

              [21]

              9

              Natural

              No

              Acute

              P vivax

              Fever, back pain

              None

              Died

                    

              severe shock

                

              [22]

              10

              Natural

              No

              Acute

              P vivax

              Fever, hypotension

              None

              Lived

                    

              diffuse peritoneal

                
                    

              signs

                

              [23]

              11

              Natural

              No

              Acute

              P falciparum

              Hypotension, Kehr's

              Splenectomy

              Lived

                    

              sign, diffuse

                
                    

              peritoneal signs

                

              [24]

              12

              Natural

              No

              Acute

              P falciparum

              Fever, LUQ pain

              Splenectomy

              Lived

              [25]

              13

              Natural

              Yes

              Acute

              P vivax

              LUQ pain,

              Splenectomy

              Lived

                    

              palpitations

                
               

              14

              Natural

              Yes

              Acute

              P vivax

              LUQ pain, fever

              Splenectomy

              Lived

              [26]

              15

              Natural

              No

              Acute

              P malariae

              Fever, headache,

              None

              Lived

                    

              LUQ pain

                

              *

              16

              Natural

              Yes

              Acute

              P vivax

              LUQ pain, fever

              Splenectomy

              Lived

              *

              17

              Natural

              Yes

              Acute

              P vivax

              Fever, palpation,

              Splenectomy

              Lived

                    

              fainting

                

              LUQ, left upper quadrant. *Reported herein.

              Splenic enlargement is very common in malarious areas of the world. It is found in 50-80% of some populations [27]. When a palpable spleen is present, it is generally appreciated within 3-4days of the onset of symptoms. If disease remains untreated, the spleen can grow. This results in greater average spleen size in a population as the prevalence of malaria increases [15]. P vivax has been the species most closely associated with rupture of the spleen in both naturally acquired and induced infections [26]. Among cases reported after 1960, nine out of 15 were due to P vivax (four cases were induced infections and five were naturally acquired infections). Both of the patients described above had P vivax infection. Spontaneous rupture of the spleen occurs almost exclusively during acute infection, and usually during the primary attack [26].

              The exact mechanism of spleen rupture is not known. However, three mechanisms have been implicated in the process [1]. The first of these mechanisms is increase in intrasplenic tension that is due to cellular hyperplasia and engorgement. Second, the spleen may be compressed by the abdominal musculature during physiological activities such as sneezing, coughing, defecation, and sitting up or turning in bed. Finally, vascular occlusion due to reticule endothelial hyperplasia, resulting in thrombosis and infarction, may be involved. This leads to interstitial and subcapsular haemorrhage and stripping of the capsule, which lead to further subcapsular haemorrhage. The distended capsule finally gives way.

              Pathological findings in spontaneous rupture of the spleen include gross and microscopic changes. On gross examination, acutely malarial spleen is dark red because of congestion, hyperaemia and deposition of haemozoin (a malarial pigment). The capsule is thin and friable. Chronic malarial spleen tends to be dark grey, with increased density of connective tissue and fibrosis, resulting in a heavy, often massively enlarged organ with a firm or hard capsule. In addition, disruption of the spleen capsule and single or multiple tears in the underlying parenchyma may be found. Tears may be small or large (grades I-IV) and may be present on any surface. In both of the cases described above, the spleen was massively enlarged.

              Microscopic examination demonstrated haemozoin, parasitized and uninfected erythrocytes, and a massive proliferation of macrophages throughout the capillaries, venous sinuses and pulp spaces. There is congestion and dilatation of sinuses and scattered thrombosis, with focal necrosis in capillaries and splenic pulp.

              Splenectomy is accepted as the treatment of choice in cases of spontaneous rupture of the spleen. Of the 17 patients described since 1960 (including those described above), 13 patients underwent surgical procedures, all of which were splenectomies. In regions in which malaria is not endemic, improved surgical techniques and supportive care, in addition to increased preoperative and postoperative risk of splenectomy, have led to attempted nonoperative management of splenic rupture in many cases of penetrating and blunt trauma [28]. Nonoperative management consists of observation for 7-14 days in the hospital, strict bed rest, and administration of fluid and blood as needed [25]. In areas in which malaria is endemic, there is growing evidence to suggest that management of spontaneous rupture of malarial spleen without splenectomy should be attempted. A conservative strategy is also reasonable in patients who travel frequently to malarious areas. Splenectomy should be reserved for those patients with severe rupture or those with continued or recurrent bleeding [26].

              Conclusion

              Changes in the structure of the spleen during the course of malaria can result in asymptomatic enlargement or complications such as haematoma formation and rupture. Primary exposure to malaria and infection with P vivax appear to be important factors in spontaneous rupture of the spleen. Malaria is still important in the southeast Anatolia region of Turkey. Prophylactic measures should be taken by tourists who travel to this region, especially those who do so during the summer.

              Authors’ Affiliations

              (1)
              Dicle University, Faculty of Medicine

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              © Current Science Ltd 2000

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