Clinical review: Medication errors in critical care
© BioMed Central Ltd 2008
Published: 12 March 2008
Medication errors in critical care are frequent, serious, and predictable. Critically ill patients are prescribed twice as many medications as patients outside of the intensive care unit (ICU) and nearly all will suffer a potentially life-threatening error at some point during their stay. The aim of this article is to provide a basic review of medication errors in the ICU, identify risk factors for medication errors, and suggest strategies to prevent errors and manage their consequences.
Health care delivery is not infallible. Errors are common in most health care systems and are reported to be the seventh most common cause of death overall . The 1999 Institute of Medicine (IOM) report, To Err is Human: Building a Safer Health System, drew public attention to the importance of patient safety . This was followed with considerable interest by the medical community . However, to date, there is little evidence that patient safety has improved . In the intensive care unit (ICU), on average, patients experience 1.7 errors per day  and nearly all suffer a potentially life-threatening error at some point during their stay . Medication errors account for 78% of serious medical errors in the ICU . The aim of this article is to provide a basic review of medication errors in the ICU as well as strategies to prevent errors and manage their consequences.
What is a medication error?
The failure of a planned action to be completed as intended or the use of a wrong plan to achieve an aim .
Any error in the medication process, whether there are adverse consequences or not .
Adverse drug event
Any injury related to the use of a drug . Not all adverse drug events are caused by medical error, nor do all medication errors result in an adverse drug event .
Preventable adverse event
Harm that could be avoided through reasonable planning or proper execution of an action .
The occurrence of an error that did not result in harm .
A failure to execute an action due to a routine behavior being misdirected .
A failure to execute an action due to lapse in memory and a routine behavior being omitted .
A knowledge-based error due to an incorrect thought process or analysis .
Error of omission
Failure to perform an appropriate action .
Error of commission
Performing an inappropriate action .
How are medication errors classified?
James Reason developed a well-recognized system for human error classification based on observations from industries that have become highly reliable such as aviation and nuclear power . He states that errors arise for two reasons: active failures and latent conditions.
Active failures are unsafe acts committed by people who are in direct contact with the patient. They take a variety of forms: slips, lapses, and mistakes (Table 1). Slips and lapses are skill-based behavior errors, when a routine behavior is misdirected or omitted. The person has the right idea but performs the wrong execution. For example, forgetting to restart an infusion of heparin postoperatively is a lapse. Restarting the heparin infusion but entering an incorrect infusion rate despite knowing the correct rate is a slip. Mistakes are knowledge-based errors (perception, judgment, inference, and interpretation) and occur due to incorrect thought processes or analyses. For example, prescribing heparin in a patient diagnosed with heparin-induced thrombo-cytopenia is a mistake. Situational factors (fatigue, drugs, alcohol, stress, and multiple activities) can divert attention and increase the risk of active failures.
Latent conditions are resident pathogens within the system. They can affect the rate at which employees execute active failures and the risks associated with active failures. Latent failures occur when individuals make decisions that have unintended consequences in the future . Prevention requires an ongoing tenacious search and corrective actions once latent conditions are identified. For example, institutions that use staffing models that depend on providers to routinely perform clinical duties above and beyond their regular responsibilities paradoxically risk introducing time pressures, fatigue, and low morale into their work force.
Errors can alternatively be classified as errors of omission or errors of commission (Table 1). Errors of omission are defined as failure to perform an appropriate action . On average, patients receive only half of the recommended care they should receive . Errors of commission are defined as performing an inappropriate action . Most studies in the patient safety literature focus on errors of commission such as wrong drug or wrong dose. Problems with effectiveness and access to drug therapy have been studied much less frequently .
How common are medication errors?
The reported incidence of medication errors varies widely between clinical settings and patient populations and between studies. Errors appear to occur in approximately 6% of hospital medication use episodes . Among critically ill adults, the rate of medication errors ranges from 1.2 to 947 errors per 1,000 patient ICU days with a median of 106 errors per 1,000 patient ICU days . In children, 100 to 400 prescribing errors have been reported per 1,000 patients . Several factors account for this large variation in reported medication errors. First, the definition of medication error, including both the numerator and denominator selected for rate calculations, is critical. For example, medication errors and adverse drug events (ADEs) are frequently reported as individual events, as a numerator, but with no denominator . Furthermore, selecting an appropriate denominator that reflects exposure to risk can be difficult . Should medication errors be reported per patient, patient day, medication day, or dose administered? Second, the process node (prescription, transcription, and so on) under investigation will influence incidence estimates . Third, the method of reporting medication errors influences rate estimates [22, 23]. Spontaneous reporting of medication errors may under-report events [11, 22]. Review of the medical records is considered by many experts the benchmark for estimating the extent of errors and adverse events in hospitals but is dependent on accurate documentation . Automation of medical record reviews with computers can be used to improve efficiency and allow for prospective reviews . Direct patient monitoring may be the ultimate reference standard but is dependent on observer expertise and is very labor-intensive . Fourth, the culture of individual ICUs, the number of ICUs participating in error reporting, and the technologies employed can significantly influence error reporting. Medication error trends over time using the same standardized measurement tools are more likely to provide valuable information than periodic cross-sectional surveys.
What are the consequences of medication errors?
Medication errors are an important cause of patient morbidity and mortality . Although only 10% of medication errors result in an ADE, these errors have profound implications for patients, families, and health care providers [13, 26, 27]. The IOM report highlights that 44,000 to 98,000 patients die each year as a result of medical errors, a large portion of these being medication-related . Approximately one fifth (19%) of medication errors in the ICU are life-threatening and almost half (42%) are of sufficient clinical importance to warrant additional life-sustaining treatments . However, deaths are only the tip of the iceberg. The human and societal burden is even greater with many patients experiencing costly and prolonged hospital stays and some patients never fully recovering to their premorbid status [29, 30]. Bates and colleagues  estimated that in American hospitals the annual cost of serious medication errors in 1995 was $2.9 million per hospital and that a 17% decrease in incidence would result in $480,000 savings per hospital. Finally, the psychological impact of errors should not be ignored . Errors erode patient, family, and public confidence in health care organizations . Memories of error can haunt providers for many years .
What is unique about the ICU and medication errors?
Risk factors for medication errors in the intensive care unit
Specific risk factors
Severity of illness
Strongest predictor of ADE [25,34]
ICU patients more likely to experience ADE than patients in other units 
Extreme of ages
Increased susceptibility to ADEs [2,78]
Increased exposure and susceptibility to ADEs [2,78]
Patients unable to participate in care and defend themselves against errors 
Types of medications
Frequent use of boluses and infusions 
Weight-based infusions derived from estimated weights or unreliable determinations 
Mathematical calculations required for medication dosages 
Programming of infusion pumps 
Number of medications
Twice as many medications prescribed as for patients in other units 
Increased probability of medication error and medication interactions 
Number of interventions
Increased risk of complications 
Difficult working conditions make errors more probable 
High stress 
High turnover of patients and providers [82,83]
Risk of an adverse event increases by approximately 6% per day [25,84]
Multiple care providers
Challenges the integration of different care plans 
How can we prevent medication errors?
Sample strategies to prevent medication errors
Optimize the medication process
1. Medication standardization
2. Computerized physician order entry and clinical decision support
3. Bar code technology
4. Computerized intravenous infusion devices
5. Medication reconciliation
Eliminate situational risk factors
1. Avoid excessive consecutive and cumulative working hours
2. Minimize interruptions and distractions
3. Trainee supervision and graduated responsibility
Oversight and error interception
1. Intensivist participation in ICU care
2. Adequate staffing
3. Pharmacist participation in ICU care
4. Incorporation of quality assurance into academic education
The safest and most efficient means of improving patient safety is to improve the safety of the medication process. Strategies that have been shown to be successful include medication standardization [40, 41], computerized physician order entry (CPOE) [42, 43], bar code technology [44, 45], computerized intravenous infusion devices , and medication reconciliation . CPOE targets the prescription and transcription stages of the medication process. The technology permits clinicians to enter orders directly into a computer workstation that is linked to a hospital clinical information system . The main advantages of these systems are that they can track allergies, recommend drug dosages, provide adjustments for patients with altered renal or hepatic function, and identify potential drug-drug interactions . Major limitations for implementation include capital costs, provider willingness to adopt the technology, and worries about technical malfunctions and paradoxical increases in medication errors during implementation periods [9, 48]. Two systematic reviews have documented that CPOE systems increase clinician adherence to guidelines and alerts, improve organizational efficiency, reduce costs, and even prevent medication errors, but there is limited evidence to support improved patient safety [42, 43]. In this regard, CPOE technology highlights the important distinction between error and harm; errors are an important intermediate outcome, but preventing patient harm is the ultimate goal . CPOE technology currently is not used in the majority of ICUs .
Bar code technologies target the administration phase of the medication process. Used in conjunction with CPOE, bar code labels for the medication, the patient, and the provider administering the medication are scanned, reconciled, and documented electronically. This process helps ensure that the correct patient gets the correct dose of the correct drug by the correct route at the correct time . Administration errors have been documented to be reduced by 60% . Computerized intravenous infusion devices allow incorporation of CPOE and bar code technology for intravenous medications such that standardized concentrations, infusion rates, and dosing limits can be provided to help prevent intravenous medication errors .
Three quarters of patient medications are stopped on patient admission to the ICU [39, 51]. Many of these medications are not restarted by the time of patient discharge from the ICU (88%) or hospital (30%) [39, 51]. Medication reconciliation is a process that matches a patient's current hospital medication regimen against a patient's long-term medication regimen. A coordinated medication reconciliation program can prevent drug withdrawal and ensure that life-saving medications are continued or restarted as soon as appropriate .
Situational risk factors can divert providers' attention and increase the risk of active failures. These need to be minimized. For example, acute and chronic sleep deprivation among residents has been shown to increase the risk of error [52, 53]. Therefore, it seems reasonable to establish clinical routines that balance the risk of provider fatigue against the risk of frequent patient sign-over . Trainee supervision and graduated responsibility represent additional risk factors that need to be managed. Clinical inexperience can have a major impact on errors. First-year residents are five times more likely to make prescribing errors than those with more experience , as are residents at the start of new rotations . Pharmacological knowledge is an independent predictor of medication errors by health care providers . It is important to capture providers when they start in new environments, train them, and then provide graduated supervision as they develop experience . Although efforts should be directed at targeting situational risk factors, it is important to note that most medication errors occur when individuals are working under what they perceive to be reasonably normal conditions and denying fatigue, stress, or distractions at the time of the error .
Physicians, nurses, and pharmacists are integral to medication oversight and error interception. Participation of an intensivist in patient care in the ICU has been reported to decrease medication errors from 22% to 70% , complications by 50% , ICU mortality, ICU length of stay, and hospital length of stay and to improve patient safety . Pharmacists, similarly, have an important role to play in medication safety. First, all intravenous medications should be prepared within the pharmacy department by pharmacists using a standardized process and standardized medication concentrations. Second, participation of a pharmacist in clinical rounds improves patient safety by reducing preventable ADEs by 66%  while shortening patients' length of hospital stay [62, 63], decreasing mortality , and decreasing medication expenditures [65, 66].
Nurses play a particularly important role in patient safety because they are the health care providers with whom patients are likely to spend the greatest amount of time. This has two important implications. One, decreasing nurse-to-patient staffing ratios may be associated with an increased risk of medical errors [67, 68]. Nurse-to-patient ratios of 1:1 or 1:2 appear to be safest in the ICU . Second, nursing experience may have an important influence on patient safety. Experienced nurses are more likely to intercept errors compared with less experienced nurses .
What can we learn from errors?
Conversely, high-reliability organizations such as aircraft carriers, nuclear power plants, and air traffic controllers have markedly improved safety by standardizing practices and investing in safety training and research [71, 73]. Three simple strategies to change medicine's approach to medication errors have been proposed : (a) recognize that current approaches for preventing medication errors are inadequate; (b) improve the error-reporting system, avoid punishment, and focus on identifying performance improvement opportunities; and (c) understand and enhance human performance within the medication use process.
We should focus on developing systems that view humans as fallible and assume that errors will occur, even in the best organizations. In this model, multiple barriers and safeguards can be developed to reduce the frequency of ADEs. Error reporting is an important component of this strategy because it reveals the active failures and latent conditions in the system . Near misses are incidents that did not lead to harm but could have resulted in patient injury. Reporting these as well as adverse events offers several advantages over reporting only adverse events. These include greater event frequency for quantitative analysis, fewer reporting barriers partly owing to fewer liability concerns, and an opportunity to study recovery patterns . Ideally, error reporting should be voluntary, anonymous, centralized to increase the pool of data, and designed to identify opportunities for performance improvement. However, error reporting alone will not improve patient safety but rather is the first step in a continuous quality improvement cycle . In addition, error reporting has its limitations. Like any intervention, it can have unintended consequences such as creating incentives for gaming the health care system, particularly if penalties or rewards are directly or indirectly associated with reporting . In addition, error reporting can be labor-intensive. For example, a 10-bed ICU could be anticipated to produce more than 6,200 error reports per year (1.7 errors per patient per day × 10 beds × 365 days). Reporting near misses would substantially increase the number of reports. Some systems such as the AIMS-ICU (Australian Incident Monitoring Study in Intensive Care) and the ICUSRS (Intensive Care Unit Safety Reporting System) have been developed with the goal of balancing the strengths and limitations of error reporting .
Patient safety is an important health care issue because of the consequences of iatrogenic injuries. Medication errors in critical care are frequent, serious, and predictable. Human factor research in nonmedical settings suggests that demanding greater vigilance from providers of medical care may not result in meaningful safety improvement. Instead, the approach of identifying failures and redesigning faulty systems appears to be a more promising way to reduce human error.
The authors thank Sharon Straus and Heather Jeppesen for their comments on an earlier draft of this manuscript.
- Medical errors: the scope of the problem. [http://www.ahrq.gov/qual/errback.htm]
- Kohn LT, Corrigan JM, Donaldson MS: To Err is Human: Building a Safer Health System. 1999, Washington: National Academy Press
- Stelfox HT, Palmisani S, Scurlock C, Orav EJ, Bates DW: The 'To Err is Human' report and the patient safety literature. Qual Saf Health Care. 2006, 15: 174-178. 10.1136/qshc.2006.017947.PubMedPubMed CentralView Article
- Leape LL, Berwick DM: Five years after To Err Is Human: what have we learned?. JAMA. 2005, 293: 2384-2390. 10.1001/jama.293.19.2384.PubMedView Article
- Donchin Y, Gopher D, Olin M, Badihi Y, Biesky M, Sprung CL, Pizov R, Cotev S: A look into the nature and causes of human errors in the intensive care unit. Crit Care Med. 1995, 23: 294-300. 10.1097/00003246-199502000-00015.PubMedView Article
- Pronovost PJ, Thompson DA, Holzmueller CG, Lubomski LH, Morlock LL: Defining and measuring patient safety. Crit Care Clin. 2005, 21: 1-19. 10.1016/j.ccc.2004.07.006.PubMedView Article
- Rothschild JM, Landrigan CP, Cronin JW, Kaushal R, Lockley SW, Burdick E, Stone PH, Lilly CM, Katz JT, Czeisler CA, Bates DW: The Critical Care Safety Study: The incidence and nature of adverse events and serious medical errors in intensive care. Crit Care Med. 2005, 33: 1694-1700. 10.1097/01.CCM.0000171609.91035.BD.PubMedView Article
- Pharmacy-nursing shared vision for safe medication use in hospitals: executive summary session. Am J Health Syst Pharm. 2003, 60: 1046-1052.
- Hussain E, Kao E: Medication safety and transfusion errors in the ICU and beyond. Crit Care Clin. 2005, 21: 91-110. 10.1016/j.ccc.2004.08.003.PubMedView Article
- Leape LL: Preventing adverse drug events. Am J Health Syst Pharm. 1995, 52: 379-382.PubMed
- Krahenbuhl-Melcher A, Schlienger R, Lampert M, Haschke M, Drewe J, Krahenbuhl S: Drug-related problems in hospitals: a review of the recent literature. Drug Safety. 2007, 30: 379-407. 10.2165/00002018-200730050-00003.PubMedView Article
- Bates DW, Cullen DJ, Laird N, Petersen LA, Small SD, Servi D, Laffel G, Sweitzer BJ, Shea BF, Hallisey R: Incidence of adverse drug events and potential adverse drug events. Implications for prevention. ADE Prevention Study Group. JAMA. 1995, 274: 29-34. 10.1001/jama.274.1.29.PubMedView Article
- Calabrese AD, Erstad BL, Brandl K, Barletta JF, Kane SL, Sherman DS: Medication administration errors in adult patients in the ICU. Intensive Care Med. 2001, 27: 1592-1598. 10.1007/s001340101065.PubMedView Article
- Leape LL, Bates DW, Cullen DJ, Cooper J, Demonaco HJ, Gallivan T, Hallisey R, Ives J, Laird N, Laffel G, Nemeskal R, Petersen LA, Porter K, Servi D, Shea BF, Small SD, Sweitzer BJ, Thompson T, Vander Vliet M, for the ADE Prevention Study Group: Systems analysis of adverse drug events. ADE Prevention Study Group. JAMA. 1995, 274: 35-43. 10.1001/jama.274.1.35.PubMedView Article
- The United States Pharmacopeial Convention: 1999. 1999, Rockville, MD: United States Pharmacopeia, 1131-1132.
- Parshuram CS, Ng GYT, Ho TKL, Klein J, Moore AM, Bohn D, Koren G: Discrepancies between ordered and delivered concentrations of opiate infusions in critical care. Crit Care Med. 2003, 31: 2483-2487. 10.1097/01.CCM.0000089638.83803.B2.PubMedView Article
- Reason J: Human Error. 1990, Cambridge: Cambridge University PressView Article
- McGlynn EA, Asch SM, Adams J, Keesey J, Hicks J, DeCristofaro A, Kerr EA: The quality of health care delivered to adults in the United States. N Engl J Med. 2003, 348: 2635-2645. 10.1056/NEJMsa022615.PubMedView Article
- Kanjanarat P, Winterstein AG, Johns TE, Hatton RC, Gonzalez-Rothi R, Segal R: Nature of preventable adverse drug events in hospitals: a literature review. Am J Health Syst Pharm. 2003, 60: 1750-1759.PubMed
- Kane-Gill S, Weber RJ: Principles and practices of medication safety in the ICU. Crit Care Clin. 2006, 22: 273-290. 10.1016/j.ccc.2006.02.005.PubMedView Article
- Miller MR, Robinson KA, Lubomski LH, Rinke ML, Pronovost PJ: Medication errors in paediatric care: a systematic review of epidemiology and an evaluation of evidence supporting reduction strategy recommendations. Qual Saf Health Care. 2007, 16: 116-126. 10.1136/qshc.2006.019950.PubMedPubMed CentralView Article
- O'Neil AC, Petersen LA, Cook EF, Bates DW, Lee TH, Brennan TA: Physician reporting compared with medical-record review to identify adverse medical events. Ann Intern Med. 1993, 119: 370-376.PubMedView Article
- Flynn EA, Barker KN, Pepper GA, Bates DW, Mikeal RL: Comparison of methods for detecting medication errors in 36 hospitals and skilled-nursing facilities. Am J Health Syst Pharm. 2002, 59: 436-446.PubMed
- Michel P, Quenon JL, de Sarasqueta AM, Scemama O: Comparison of three methods for estimating rates of adverse events and rates of preventable adverse events in acute care hospitals. BMJ. 2004, 328: 199-10.1136/bmj.328.7433.199.PubMedPubMed CentralView Article
- Andrews LB, Stocking C, Krizek T, Gottlieb L, Krizek C, Vargish T, Siegler M: An alternative strategy for studying adverse events in medical care. Lancet. 1997, 349: 309-313. 10.1016/S0140-6736(96)08268-2.PubMedView Article
- Bates DW, Boyle DL, Vander Vliet MB, Schneider J, Leape L: Relationship between medication errors and adverse drug events. J Gen Intern Med. 1995, 10: 199-205. 10.1007/BF02600255.PubMedView Article
- Barker KN, Flynn EA, Pepper GA, Bates DW, Mikeal RL: Medication errors observed in 36 health care facilities. Arch Intern Med. 2002, 162: 1897-1903. 10.1001/archinte.162.16.1897.PubMedView Article
- Tissot E, Cornette C, Demoly P, Jacquet M, Barale F, Capellier G: Medication errors at the administration stage in an intensive care unit. Intensive Care Med. 1999, 25: 353-359. 10.1007/s001340050857.PubMedView Article
- Classen DC, Pestotnik SL, Evans RS, Lloyd JF, Burke JP: Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. JAMA. 1997, 277: 301-306. 10.1001/jama.277.4.301.PubMedView Article
- Bates DW, Leape LL, Cullen DJ, Laird N, Petersen LA, Teich JM, Burdick E, Hickey M, Kleefield S, Shea B, Vander Vliet M, Seger DL: Effect of computerized physician order entry and a team intervention on prevention of serious medication errors. JAMA. 1998, 280: 1311-1316. 10.1001/jama.280.15.1311.PubMedView Article
- Cohen H, Mandrack MM: Application of the 80/20 rule in safeguarding the use of high-alert medications. Crit Care Nurs Clin North Am. 2002, 14: 369-374. 10.1016/S0899-5885(02)00018-7.PubMedView Article
- Christensen JF, Levinson W, Dunn PM: The heart of darkness: the impact of perceived mistakes on physicians. J Gen Intern Med. 1992, 7: 424-431. 10.1007/BF02599161.PubMedView Article
- Pronovost PJ, Weast B, Holzmueller CG, Rosenstein BJ, Kidwell RP, Haller KB, Feroli ER, Sexton JB, Rubin HR: Evaluation of the culture of safety: survey of clinicians and managers in an academic medical center. Qual Saf Health Care. 2003, 12: 405-410. 10.1136/qhc.12.6.405.PubMedPubMed CentralView Article
- Giraud T, Dhainaut JF, Vaxelaire JF, Joseph T, Journois D, Bleichner G, Sollet JP, Chevret S, Monsallier JF: Iatrogenic complications in adult intensive care units: a prospective two-center study. Crit Care Med. 1993, 21: 40-51. 10.1097/00003246-199301000-00011.PubMedView Article
- Cullen DJ, Sweitzer BJ, Bates DW, Burdick E, Edmondson A, Leape LL: Preventable adverse drug events in hospitalized patients: a comparative study of intensive care and general care units. Crit Care Med. 1997, 25: 1289-1297. 10.1097/00003246-199708000-00014.PubMedView Article
- Ridley SA, Booth SA, Thompson CM, Clayton T, Eddleston J, Mackenzie S, Thomas T, Webb A, Wright D: Prescription errors in UK critical care units. Anaesthesia. 2004, 59: 1193-1200. 10.1111/j.1365-2044.2004.03969.x.PubMedView Article
- Kollef MH, Sherman G, Ward S, Fraser VJ: Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest. 1999, 115: 462-474. 10.1378/chest.115.2.462.PubMedView Article
- Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH: The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000, 118: 146-155. 10.1378/chest.118.1.146.PubMedView Article
- Campbell AJ, Bloomfield R, Noble DW: An observational study of changes to long-term medication after admission to an intensive care unit. Anaesthesia. 2006, 61: 1087-1092. 10.1111/j.1365-2044.2006.04831.x.PubMedView Article
- Larsen GY, Parker HB, Cash J, O'Connell M, Grant MC: Standard drug concentrations and smart-pump technology reduce continuous-medication-infusion errors in pediatric patients. Pediatrics. 2005, 116: e21-25. 10.1542/peds.2004-2452.PubMedView Article
- Bullock J, Jordan D, Gawlinski A, Henneman EA: Standardizing IV infusion medication concentrations to reduce variability in medication errors. Crit Care Nurs Clin North Am. 2006, 18: 515-521. 10.1016/j.ccell.2006.08.008.PubMedView Article
- Shamliyan TA, Duval S, Du J, Kane RL: Just what the doctor ordered. Review of the evidence of the impact of computerized physician order entry system on medication errors. Health Serv Res. 2008, 43 (1 Pt 1): 32-53.PubMedPubMed Central
- Eslami S, Abu-Hanna A, De Keizer NF, De Jonge E: Errors associated with applying decision support by suggesting default doses for aminoglycosides. Drug Safety. 2006, 29: 803-809. 10.2165/00002018-200629090-00004.PubMedView Article
- Williams CK, Maddox RR: Implementation of an i.v. medication safety system. Am J Health Syst Pharm. 2005, 62: 530-536.PubMed
- Cummings J, Bush P, Smith D, Matuszewski K: Bar-coding medication administration overview and consensus recommendations. Am J Health Syst Pharm. 2005, 62: 2626-2629. 10.2146/ajhp050222.PubMedView Article
- Pronovost P, Weast B, Schwarz M, Wyskiel RM, Prow D, Milanovich SN, Berenholtz S, Dorman T, Lipsett P: Medication reconciliation: a practical tool to reduce the risk of medication errors. J Crit Care. 2003, 18: 201-205. 10.1016/j.jcrc.2003.10.001.PubMedView Article
- Sittig DF, Stead WW: Computer-based physician order entry: the state of the art. J Am Med Inform Assoc. 1994, 1: 108-123.PubMedPubMed CentralView Article
- Weant KA, Cook AM, Armitstead JA: Medication-error reporting and pharmacy resident experience during implementation of computerized prescriber order entry. Am J Health Syst Pharm. 2007, 64: 526-530. 10.2146/ajhp060001.PubMedView Article
- Eslami S, Keizer NF, Abu-Hanna A: The impact of computerized physician medication order entry in hospitalized patients-A systematic review. Int J Med Inform. 2007, Nov 17,
- Ash JS, Gorman PN, Seshadri V, Hersh WR: Computerized physician order entry in U.S. hospitals: results of a 2002 survey. J Am Med Inform Assoc. 2004, 11: 95-99. 10.1197/jamia.M1427.PubMedPubMed CentralView Article
- Bell CM, Rahimi-Darabad P, Orner AI: Discontinuity of chronic medications in patients discharged from the intensive care unit. J Gen Intern Med. 2006, 21: 937-941. 10.1007/BF02743141.PubMedPubMed CentralView Article
- Stampi C: Ultrashort sleep/wake patterns and sustained performance. Sleep and Alertness: Chronobiological, Behavioral, and Medical Aspects of Napping. Edited by: Dinges DFB, Broughton RJ. 1989, New York: Raven Press, 456-
- Landrigan CP, Rothschild JM, Cronin JW, Kaushal R, Burdick E, Katz JT, Lilly CM, Stone PH, Lockley SW, Bates DW, Czeisler CA: Effect of reducing interns' work hours on serious medical errors in intensive care units. N Engl J Med. 2004, 351: 1838-1848. 10.1056/NEJMoa041406.PubMedView Article
- Drazen JM: Awake and informed. N Engl J Med. 2004, 351: 1884-10.1056/NEJMe048276.PubMedView Article
- Lesar TS, Briceland LL, Delcoure K, Parmalee JC, Masta-Gornic V, Pohl H: Medication prescribing errors in a teaching hospital. JAMA. 1990, 263: 2329-2334. 10.1001/jama.263.17.2329.PubMedView Article
- LaPointe NM, Jollis JG: Medication errors in hospitalized cardiovascular patients. Arch Intern Med. 2003, 163: 1461-1466. 10.1001/archinte.163.12.1461.PubMedView Article
- Wasserfallen JB, Butschi AJ, Muff P, Biollaz J, Schaller MD, Pannatier A, Revelly JP, Chiolero R: Format of medical order sheet improves security of antibiotics prescription: The experience of an intensive care unit. Crit Care Med. 2004, 32: 655-659. 10.1097/01.CCM.0000114835.97789.AB.PubMedView Article
- Van Den Bemt PMLA, Fijn R, Van Der Voort PHJ, Gossen AA, Egberts TCG, Brouwers JRBJ: Frequency and determinants of drug administration errors in the intensive care unit. Crit Care Med. 2002, 30: 846-850. 10.1097/00003246-200204000-00022.PubMedView Article
- Pronovost PJ, Angus DC, Dorman T, Robinson KA, Dremsizov TT, Young TL: Physician staffing patterns and clinical outcomes in critically ill patients: a systematic review. JAMA. 2002, 288: 2151-2162. 10.1001/jama.288.17.2151.PubMedView Article
- Durbin CG: Team model: advocating for the optimal method of care delivery in the intensive care unit. Crit Care Med. 2006, 34 (3 Suppl): S12-17. 10.1097/01.CCM.0000199985.72497.D1.PubMedView Article
- Leape LL, Brennan TA, Laird N, Lawthers AG, Localio AR, Barnes BA, Hebert L, Newhouse JP, Weiler PC, Hiatt H: The nature of adverse events in hospitalized patients. Results of the Harvard Medical Practice Study II. N Engl J Med. 1991, 324: 377-384.PubMedView Article
- Bjornson DC, Hiner WO, Potyk RP, Nelson BA, Lombardo FA, Morton TA, Larson LV, Martin BP, Sikora RG, Cammarata FA: Effect of pharmacists on health care outcomes in hospitalized patients. Am J Hosp Pharm. 1993, 50: 1875-1884.PubMed
- Boyko WL, Yurkowski PJ, Ivey MF, Armitstead JA, Roberts BL: Pharmacist influence on economic and morbidity outcomes in a tertiary care teaching hospital. Am J Health Syst Pharm. 1997, 54: 1591-1595.PubMed
- Bond CA, Raehl CL: Clinical pharmacy services, pharmacy staffing, and hospital mortality rates. Pharmacotherapy. 2007, 27: 481-493. 10.1592/phco.27.4.481.PubMedView Article
- Montazeri M, Cook DJ: Impact of a clinical pharmacist in a multidisciplinary intensive care unit. Crit Care Med. 1994, 22: 1044-1048. 10.1097/00003246-199406000-00027.PubMedView Article
- Baldinger SL, Chow MS, Gannon RH, Kelly ET: Cost savings from having a clinical pharmacist work part-time in a medical intensive care unit. Am J Health Syst Pharm. 1997, 54: 2811-2814.PubMed
- Beckmann U, Baldwin I, Durie M, Morrison A, Shaw L: Problems associated with nursing staff shortage: an analysis of the first 3600 incident reports submitted to the Australian Incident Monitoring Study (AIMS-ICU). Anaesth Intensive Care. 1998, 26: 396-400.PubMed
- Whitman GR, Kim Y, Davidson LJ, Wolf GA, Wang SL: The impact of staffing on patient outcomes across specialty units. J Nurs Adm. 2002, 32: 633-639. 10.1097/00005110-200212000-00008.PubMedView Article
- Pronovost P, Wu AW, Dorman T, Morlock L: Building safety into ICU care. J Crit Care. 2002, 17: 78-85. 10.1053/jcrc.2002.34363.PubMedView Article
- Hanneman SK: Advancing nursing practice with a unit-based clinical expert. Image J Nurs Sch. 1996, 28: 331-337. 10.1111/j.1547-5069.1996.tb00383.x.PubMedView Article
- Reason J: Human error: models and management. BMJ. 2000, 320: 768-770. 10.1136/bmj.320.7237.768.PubMedPubMed CentralView Article
- Al-Ansari MA, Hijazi MH: Medical errors and adverse events: focus on the intensive care unit. Clinical Intensive Care. 2006, 17: 9-17. 10.1080/09563070600576196.View Article
- Bion JF, Heffner JE: Challenges in the care of the acutely ill. Lancet. 2004, 363: 970-977. 10.1016/S0140-6736(04)15793-0.PubMedView Article
- Crane VS: New perspectives on preventing medication errors and adverse drug events. Am J Health Syst Pharm. 2000, 57: 690-697.PubMed
- Barach P, Small SD: Reporting and preventing medical mishaps: lessons from non-medical near miss reporting systems. BMJ. 2000, 320: 759-763. 10.1136/bmj.320.7237.759.PubMedPubMed CentralView Article
- Stelfox HT, Bates DW, Redelmeier DA: Safety of patients isolated for infection control. JAMA. 2003, 290: 1899-1905. 10.1001/jama.290.14.1899.PubMedView Article
- ASHP guidelines on preventing medication errors in hospitals. Am J Hosp Pharm. 1993, 50: 305-314.
- Weingart SN, Wilson RM, Gibberd RW, Harrison B: Epidemiology of medical error. BMJ. 2000, 320: 774-777. 10.1136/bmj.320.7237.774.PubMedPubMed CentralView Article
- Herout PM, Erstad BL: Medication errors involving continuously infused medications in a surgical intensive care unit. Crit Care Med. 2004, 32: 428-432. 10.1097/01.CCM.0000108876.12846.B7.PubMedView Article
- Stambouly JJ, McLaughlin LL, Mandel FS, Boxer RA: Complications of care in a pediatric intensive care unit: a prospective study. Intensive Care Med. 1996, 22: 1098-1104. 10.1007/BF01699236.PubMedView Article
- Donchin Y, Seagull FJ: The hostile environment of the intensive care unit. Curr Opin Crit Care. 2002, 8: 316-320. 10.1097/00075198-200208000-00008.PubMedView Article
- Pronovost PJ, Jenckes MW, Dorman T, Garrett E, Breslow MJ, Rosenfeld BA, Lipsett PA, Bass E: Organizational characteristics of intensive care units related to outcomes of abdominal aortic surgery. JAMA. 1999, 281: 1310-1317. 10.1001/jama.281.14.1310.PubMedView Article
- Bria WF, Shabot MM: The electronic medical record, safety, and critical care. Crit Care Clin. 2005, 21: 55-79. 10.1016/j.ccc.2004.08.001. viiiPubMedView Article
- Brennan TA, Leape LL, Laird NM, Hebert L, Localio AR, Lawthers AG, Newhouse JP, Weiler PC, Hiatt HH: Incidence of adverse events and negligence in hospitalized patients. Results of the Harvard Medical Practice Study I. N Engl J Med. 1991, 324: 370-376.PubMedView Article