Volume 12 Supplement 2
Finger reactive hyperaemia to measure endothelial function in sepsis and health (the FRESH study)
© BioMed Central Ltd 2008
Published: 13 March 2008
Endothelial dysfunction is thought to be an important mechanism of organ failure in sepsis. We hypothesised that endothelial function (EF) would be impaired in adult patients with sepsis; that it would improve with treatment; and that the degree of its impairment would correlate with disease severity and outcome.
EF was measured using a novel, noninvasive technique at the bedside (reactive hyperaemia peripheral arterial tonometry (RH-PAT)) in three groups: patients with sepsis requiring admission to the ICU (ICU sepsis); patients with sepsis requiring hospital but not ICU admission (ward sepsis); and control patients without sepsis. Measurements were taken on days 0, 2 and 7 in the sepsis patients and at baseline in the control patients.
Noninvasive measurement of EF is feasible in sepsis. EF in sepsis is initially markedly impaired. It improves over the first 2 days in those patients with moderate sepsis but not in those with sepsis requiring ICU admission. These data will be further analysed to explore correlations, and blood samples have been stored for the measurement of serum arginine and markers of endothelial activation.
This article is published under license to BioMed Central Ltd.