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Table 4 Hemodynamic and perfusion variables during surgery and postoperatively

From: Prospective, randomized trial comparing fluids and dobutamine optimization of oxygen delivery in high-risk surgical patients [ISRCTN42445141]

 

0

1

2

3

4

5

6

7

8

9

10

11

12

Cardiac index (l/minute/m2)

             

   Volume group

3.6/1.1 (25)

3.2/1.1 (25)

3.3/0.8 (22)

3.5/0.6 (15)

3.4/0.8 (13)

3.9/0.8 (4)

2.5/0.7

2.9/0.8

3.1/0.9

3.2/0.8

3.5/0.9

3.8/1.2

3.7/0.6

   Dobutamine group

3.4/0.7 (25)

3.0/0.8 (25)

4.0/1.0*# (22)

4.6/1.2* # (13)

4.5/0.5* # (10)

4.6/0.7# (8)

3.0/0.9*

3.6/1.0*

3.8/1.0*

3.9/0.8* #

3.9/0.7#

4.0/0.8#

4.0/0.9#

Left ventricular stroke work index (g/m/m2)

             

   Volume group

65/22 (25)

43/12# (25)

43/12# (22)

41/13# (15)

46/12# (10)

45/11 (4)

37/13#

37/15#

41/23#

42/28#

46/18#

45/22#

42/18#

   Dobutamine group

58/15 (25)

43/13# (25)

49/17 (22)

48/9* # (13)

50/14 (10)

49/18 (8)

39/18#

43/20#

41/19#

42/21#

41/20#

43/17#

42/16#

Pulmonary artery occlusion pressure (mmHg)

             

   Volume group

12/4.3 (25)

12/4.3 (25)

10/3.0 (22)

10/3.0 (14)

11/3.3 (12)

8/1.1 (3)

9/4.1

11/4.7

13/4.5

11/4.6

12/3.5

12/3.3

12/3.9

   Dobutamine group

11/4.0 (25)

12/3.3 (25)

10/2.9 (22)

9/2.5 (13)

8/1.6* # (10)

10/1.1 (8)

9/3.3

10/3.9

11/3.5

11/4.4

11/4.4

11/3.7

12/3.3

Lactate (mEq/l)

             

   Volume group

1.3/0.6

1.3/0.6

1.2/0.5

1.7/0.6

2.5/1.6

2.8/2.0

2.5/1.6

2.8/1.9

2.0/1.9

2.2/2.0

2.1/2.4

1.9/1.8

1.9/2.0

   Dobutamine group

1.3/0.5

1.4/0.8

1.9/0.6

1.2/0.4

2.2/0.8

1.9/0.8

2.2/0.8

1.9/0.8

1.6/0.6

1.6/0.8

1.7/0.8

1.3/0.8

1.3/0.4

Mixed venous oxygen saturation (%)

             

   Volume group

83/4

-

86/3

86/5

86/5

86/2

76/13

73/11

76/15

77/10

77/10

77/11

78/9

   Dobutamine group

81/6

-

86/2

87/5

85/6

83/11

78/9

80/10

80/9

77/11

79/7

77/8

77/8

  1. Results presented as mean/standard deviation. 0, preoperative; 1, 30 minutes intraoperatively; 2, 2 hours intraoperatively; 3, 4 hours intraoperatively; 4, 6 hours intraoperatively; 5, 8 hours intraoperatively; 6, 0 hours postoperatively; 7, 4 hours postoperatively; 8, 8 hours postoperatively; 10, 12 hours postoperatively; 11, 16 hours postoperatively; 12, 24 hours postoperatively. *P < 0.05 versus volume group, #P < 0.05 versus baseline.