Volume 16 Supplement 1
Does tight glycemic control positively impact on patient mortality?
© Penning et al.; licensee BioMed Central Ltd. 2012
Published: 20 March 2012
High and variable blood glucose (BG) levels have been associated with increased mortality. Tight glycemic control (TGC) aims at reducing BG levels to improve patient outcome and mortality. This research evaluates the impact of TGC on mortality.
This study used glycemic data from 1,488 patients of two cohorts: Glucontrol (n = 704) and SPRINT (n = 784). TGC glycemic outcome is measured by cumulative time in the 4 to 7 mmol/l band (cTIB), defined daily for each patient. Each day, patients were divided into two groups: cTIB <70% and cTIB ≥70%. For each group, odds of living (OL = #lived/#died) was calculated.
Results show that, irrespective of TGC protocols, high cTIB and thus normoglycemia are associated with higher odds of living. This suggests that TGC positively influences patient outcome.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.