Table 1 Impact of hyperoxia on gut-associated morbidity in clinical studies
From: Impact of hyperoxia on the gut during critical illnesses
Study name (sample size) | Settings | Lower versus higher oxygenation targets | Primary outcomes | Gut-associated morbidity |
|---|---|---|---|---|
LOCO2 [69] | Acute respiratory distress syndrome in adults | SPO2 = 88- 92% vs. SPO2 ≥ 96% | The conservative oxygenation strategy did not increase survival at 28 days | Five mesenteric ischemic events occurred in the conservative oxygen group |
(n = 205) | ||||
HOT-ICU [70] | Acute hypoxemic respiratory failure in adults | PaO2 = 60 mmHg vs. PaO2 = 90 mmHg | No significant difference in 90-day mortality between the two groups | No significant difference in intestinal ischemia between the two groups |
(n = 2928) | ||||
BOOST NZ [77] | Preterm infants | SpO2 = 85%-89% vs. SpO2 = 91%-95% | No significant difference in mortality between the two groups | No significant difference in NEC between the two groups |
(n = 340) | ||||
BOOST II AUS [78] | Preterm infants | SpO2 = 85%-89% vs. SpO2 = 91%-95% | No significant difference in mortality between the two groups | No significant difference in NEC between the two groups |
(n = 1135) | ||||
BOOST II UK [79] | Preterm infants | SpO2 = 85%-89% vs. SpO2 = 91%-95% | Lower oxygenation target was associated with increased mortality | Lower oxygenation target increased the incidence of NEC |
(n = 2448) | ||||
COT [80] | Preterm infants | SpO2 = 85%-89% vs. SpO2 = 91%-95% | No significant difference in mortality between the two groups | No significant difference in NEC between the two groups |
(n = 1201) | ||||
SUPPORT [76] | Preterm infants | SpO2 = 85%-89% vs. SpO2 = 91%-95% | No significant difference in mortality between the two groups | No significant difference in NEC between the two groups |
(n = 1316) | ||||
Meta-analysis by Askie et al. [75] | Preterm infants | SpO2 = 85%-89% vs. SpO2 = 91%-95% | Lower oxygenation target was associated with increased mortality | Lower oxygenation target increased the incidence of NEC |
(n = 4965) | ||||
Meta-analysis by Kuh et al. [94] | Gastrointestinal surgery in adults | FiO2 = 30% vs. FiO2 = 80% | High FiO2 reduced the incidence of SSI | High FiO2 decreased the anastomotic leakage incidence |
(n = 15,877) | ||||
PROXI [95] | Acute or elective laparotomy in adults | FiO2 = 30% vs. FiO2 = 80% | No significant difference in SSI incidence between the two groups | No significant difference in anastomotic leakage between the two groups |
(n = 1400) |