Table 1 Characteristics of included studies
First author, year | Country | No. of centers | Study design | Patients | Ketamine dose, mg/kg | Comparator | Timepoint of mortality assessment |
|---|---|---|---|---|---|---|---|
Jabre [21] | France | 65 | RCT | Adult patients requiring emergency intubation | 2 | Etomidate | 28Â days |
Punt [22] | Netherlands | 1 | RCT | Critically ill adult patients intubated in the ICU | 0.5 | Etomidate | 28Â days |
Van Berkel [28] | US | 1 | PS-matched | Septic patients requiring prehospital intubation | 1.8 | Etomidate | Hospital discharge |
Smischney [23] | US | 1 | RCT | Critically ill adults who admitted to ICU and required emergency intubation | 0.5a | Etomidate | Hospital discharge |
Driver [24] | US | 1 | RCT | Adult trauma patients undergoing RSI in the ED | 2 | Etomidate | 30Â days |
Powers [25] | US | 1 | RCT | Adult patients requiring RSI | 2 | Etomidate | Hospital discharge |
Matchett [26] | US | 1 | RCT | Adults requiring emergency intubation | 1–2 | Etomidate | 28 days |
Srivilaithon [27] | Thailand | 1 | RCT | Adult patients with suspected sepsis requiring intubation in the ED | 1–2 | Etomidate | 28 days |