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Table 2 Fluid balance variables during surgery and in the first postoperative morning

From: Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial

 

Ringer

5% albumin

20% albumin

P-value

Surgery

Duration of surgery (min)

325 [302, 377]

347 [336, 404]

343 [321, 373]

0.487

Hemorrhagic phase (min)

64 [51, 80]

56 [45, 69]

58 [50, 75]

0.836

Blood loss (mL)

694 [601, 1306]

862 [600, 1095]

832 [749, 1165]

0.900

Crystalloids (mL)

2800 [2350, 4200]

2182 [1500, 2400]*

2000 [1700, 2300]*

0.003

Albumin (mL)

0

884 ± 215

239 ± 48*

 < 0.001

PRBC (yes)

2/11 (15%/85%)

0/14 (0%/100%)

0/14 (0%/100%)

0.339

FFP (yes)

1/13 (8%/92%)

0/14 (0%/100%)

1/13 (7%/93%)

0.338

Norepinephrine (mg)

1.52 [0.74, 2.60]

1.12 [0.79, 1.17]

1.01 [0.75, 1.25]

0.218

Postoperative Day 1

Total fluid IN (first 24 h)

5250 [4430, 6550]

5100 [4580, 5570]

4695 [4330, 5200]

0.417

Total fluid OUT (first 24 h)

2850 [1980, 3230]

2730 [2145, 3270]

2245 [1830, 2740]

0.182

Fluid balance (first 24 h)

2610 [1330, 3995]

2335 [1630, 2540]

2525 [2025, 2940]

0.731

Change in body weight (kg)

1.90 [1.00, 3.10]

0.75 [-0.10, 1.90]

0.90 [0.50, 1.70]

0.100

B-Hb (g/L)

85 [79, 99]

85 [83, 98]

84 [72, 92]

0.709

  1. Data are given as the median [IQR], mean ± SD, or incidence (%)
  2. *P < 0.002 compared to Ringer group; + P < 0.002 compared to 5% albumin
  3. PRBC packed red blood cells, FFP fresh frozen plasma, B-Hb blood hemoglobin value, GFR glomerular filtration rate