Table 1 Baseline Characteristics by Clinical Sepsis Phenotype
|  | S (n = 696) | SS (n = 1495) | SqS (n = 265) | SSqS (n = 2370) | Overall (n = 4826) | p |
|---|---|---|---|---|---|---|
Age | 68 [55, 79] | 62 [49,72] | 68 [57, 78] | 65 [51, 76] | 64.0 [51, 76] | 0.211 |
Male Sex (%) | 427 (61.4) | 904 (60.5) | 159 (60.0) | 1486 (62.7) | 2976 (61.7) | 0.509 |
Income Country/Region (%) | ||||||
 Low/Lower Middle Income | 167 (24.0) | 445 (29.8) | 77 (29.1) | 780 (32.9) | 1469 (30.4) |  < 0.001 |
 Upper Middle Income | 317 (45.5) | 627 (41.9) | 94 (35.5) | 816 (34.4) | 1854 (38.4) |  |
 High Income | 212 (30.5) | 423 (28.3) | 94 (35.5) | 774 (32.7) | 1503 (31.1) |  |
Positive Microbiology (%) | 474 (68.1) | 955 (63.9) | 183 (69.1) | 1670 (70.5) | 3282 (68.0) |  < 0.001 |
Antibiotics within 3 Hours (%) | 481 (69.1) | 1110 (74.2) | 198 (74.7) | 1691 (71.4) | 3480 (72.1) | 0.139 |
SIRS | 1 [0, 1] | 2 [2, 3] | 1 [1] | 3 [2, 3] | 2 [2, 3] |  < 0.001 |
qSOFA | 1 [0, 1] | 1 [1] | 2 [2] | 2 [2, 3] | 2 [1, 2] |  < 0.001 |
SOFA | 6 [4, 9] | 6 [3, 9] | 8 [5, 11] | 8 [6, 11] | 7 [4, 10] |  < 0.001 |
APACHE II | 17 [12, 22] | 17 [12, 22] | 21 [15, 28] | 22 [17, 28] | 20 [14, 26] |  < 0.001 |
Lactate | 1.6 [1.1, 2.8] | 2.1 [1.3, 3.6] | 2.1 [1.2, 3.5] | 2.8 [1.6, 5] | 2.3 [1.4, 4.2] |  < 0.001 |
Vasopressors (%) | 420 (60.3) | 907 (60.7) | 200 (75.5) | 1818 (76.7) | 3345 (69.3) |  < 0.001 |
MV (%) | 507 (72.8) | 1008 (67.4) | 204 (77.0) | 1824 (77.0) | 3543 (73.4) |  < 0.001 |
RRT (%) | 198 (28.4) | 443 (29.6) | 85 (32.1) | 790 (33.3) | 1516 (31.4) | 0.025 |
ICU LOS, days | 13 [6, 27] | 11 [5, 22] | 13 [6, 29] | 11 [6, 23] | 12 [6, 23] | 0.426 |
Hospital LOS, days | 23 [13, 43] | 21 [11, 37] | 24 [13, 41] | 20 [11, 38] | 21 [11, 38] | 0.179 |