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Fig. 4 | Critical Care

Fig. 4

From: Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Fig. 4

The protective effect of interleukin (IL)-36R on lung injury in CLP mice. A The histological images of H&E stained lung sections; the scale Bar = 100 μm. B Total lung injury score obtained from 5 pathophysiological characteristics based on the histological images. C Alveolar neutrophils score. D Interstitial neutrophils score. E Hyaline membranes score. F Proteinaceous debris score. G Alveolar septal thickening score. H Representative flow cytometry plots showing the frequency of neutrophils(Ly6G+), in lung tissue. I Pooled flow cytometry data. Three independent experiments were performed thrice. NS not significant; P ≤ 0.05 were considered statistically significant. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001

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Critical Care

ISSN: 1364-8535