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Table 2 Multinomial regression testing the association between use of epinephrine and outcomes

From: Cumulative dose of epinephrine and mode of death after non-shockable out-of-hospital cardiac arrest: a registry-based study

 

Cardiocirculatory death

Neurological death

Other death

 

aOR 95%CI

p value

aOR 95%CI

p value

aOR 95%CI

p value

Epinephrine during CPR

      

 0 mg

Reference

 

Reference

 

Reference

 

 1 mg

 2–5 mg

 > 5 mg

3.45 (2.01–5.92)

12.28 (7.52–20.06)

23.71 (11.02–50.97)

 < 0.001

 < 0.001

 < 0.001

4.40 (2.79–6.94)

8.88 (5.80–13.59)

10.26 (4.94–21.31)

 < 0.001

 < 0.001

 < 0.001

2.69 (1.49–4.85)

5.95 (3.49–10.13)

7.45 (3.20–17.33)

0.001

 < 0.001

 < 0.001

  1. Reference population: alive at hospital discharge
  2. Adjustment variables: gender, age, location, witnessed OHCA, bystander CPR, no-flow duration, initial electrical rhythm, low-flow duration, medical history: heart disease, cancer, renal disease, high blood pressure, ECMO use, coronary angioplasty intervention, TTM, post-resuscitation shock, presumed cardiac cause
  3. aOR, adjusted odds ratio; 95%CI, 95% confidence interval; OHCA, out-of-hospital cardiac arrest; CPR, cardiopulmonary resuscitation; ECMO, extracorporeal membrane oxygenation; TTM, targeted temperature management
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